Senior / Medical Director, Neurosciences (Neuroscience Physician)

AstraZeneca UK

Location: Cambridgeshire, Cheshire East

Job Type: Full time


Perfection not required
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Competitive salary and benefits

Locations – Cambridge or Macclesfield (UK) or Gothenberg (Sweden)

Make a more meaningful impact to patients’ lives around the globe

Here you can make a meaningful difference to patients’ lives. With science at its heart, this is the place where breakthroughs born in the lab become transformative medicines – for the world’s most complex diseases. Answer unmet medical needs by pioneering the next wave of science, focusing on outcomes and shaping the patient ecosystem!

We are a global, science-led BioPharmaceutical business and our innovative medicines are used by millions of patients worldwide.

Here we get to develop and grow – whether that’s working at the leading-edge or on varied stages and molecules. Working on things that have never been done before. In return, when great science comes alive, we have the opportunity to get published.

What you’ll do

We are looking for an experienced physician to join a group of neuroscience drug discovery and clinical development researchers in AstraZeneca Biopharmaceuticals R&D. You will work alongside three physician colleagues and will report to the head of clinical development for neurosciences.

You role will be to drive clinical development tasks enabling delivery of a neuroscience portfolio of large and small molecules through late discovery and early clinical development using internal and external resources.

You will provide medical leadership and contribute to the development of assets transitioning from discovery through the early stages of clinical development (Phase 1 to completion of Phase 2).

You will lead clinical studies relevant to the project in line with defined operating procedures, including study design, development of the clinical protocol and other study-related documents, study execution, medical monitoring and reporting of study outcomes.

Other responsibilities include:

  • Serving as sponsor medical monitor and safety physician for clinical trials with responsibility for medical monitoring, safety surveillance and ongoing Benefit-Risk evaluation with Patient Safety and Pharmacovigilance colleagues

  • Reviewing and interpreting study results. Analyzing and synthesizing clinical data for publication, and international regulatory filings. Authoring clinical publications or providing input into communication and publication development.

  • Establishing close collaboration between company experts, including regulatory, patient safety, bio-pharmaceutical development, discovery, translational and pharmacology/toxicology sciences, to design, initiate and expedite clinical studies.

  • Engaging in planning and leading of advisory boards, data & safety monitoring boards and other scientific committees.

  • Supporting assets transitioning from the pre-clinical portfolio into clinical development, with a key role in defining the early clinical development.

  • Selection and management of collaborators and vendors including academic groups, CROs, and technical expertise or services within AZ.

  • Contributing to development of disease area strategies that integrate discovery research with clinical approaches to proof-of-concept in appropriate patient segments.

  • Evaluating and recommending licensing and acquisition opportunities, in balance with internal R&D Biopharmaceuticals efforts, and in partnership with neuroscience LT members. Participating in due diligence activities.

  • Promoting AstraZeneca R&D Biopharmaceuticals and AZ Neuroscience externally in the scientific and business and investment communities.

  • Actively participate in co-partnering discussions providing your expertise to joint steering committees and/or clinical co-development teams.

Essential criteria

  • Prior experience and successful track-record of operating in industry-sponsored clinical R&D is essential, most likely achieved within the setting of a pharmaceutical company or contract research organisation (CRO).

  • A track record of medical competencies and decision-making capabilities achieved in a clinical practice setting (at least to the level of senior resident or consultant/ attending physician in a relevant medical speciality).

  • An excellent communicator and collaborative team worker, with medical leadership skills, and the ability to interact in a cross-functional environment.

Qualifications required:

MD, MBBS, MBChB or equivalent.

Are you already imagining yourself joining our team?

So, what’s next?

Complete your application before the below closing date.

This role is open from 22, September, 2022 and we welcome your application no later than 6, October, 2022.

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognizing their potential.

Join us on our journey of building a new kind of organization to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening new ways to work, pioneering groundbreaking methods and bringing unexpected teams together.

Where can I find out more?

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Date Posted


Closing Date


AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

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