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Scientist (Oncology Safety Science,  Clinical Pharmacology & Safety Sciences)

AstraZeneca UK

Location: Cambridgeshire

Job Type: Full time

Posted

Men
16%
Women
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Women are 16% less likely than men to apply to a job once they’ve viewed it, but are 16% more likely to get hired after applying to a job.*
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Scientist (Oncology Safety Science, Clinical Pharmacology & Safety Sciences)

Cambridge UK

Salary & Benefits Competitive

Make a more meaningful impact to patients’ lives around the globe

Here you’ll have the opportunity to make a meaningful difference to patients’ lives. With science at its heart, this is the place where breakthroughs born in the lab become transformative medicines – for the world’s most complex diseases. Answer unmet medical needs by pioneering the next wave of science, focusing on outcomes and shaping the patient ecosystem.

Join a key international site for AstraZeneca. Discover countless opportunities to grow and develop your personal career, experience and skills.

Always advancing our scientific knowledge and helping to shape the future of healthcare for the greatest and swiftest impact on disease.

We are seeking highly motivated, skilled Scientists with experience in cell biology.

You will have the opportunity to work closely with a team of Scientists to apply ground-breaking technologies and push the boundaries of predictive safety science with our vision in mind: to deliver innovative safety science to help restore oncology patient's lives and eliminate cancer as a cause of death

What you will be doing

You will apply in vitro advanced cellular systems to help drive our predictive toxicology capabilities.

You will support specialists across the Oncology Safety organization to execute experimental strategies using advanced in vitro models to assess and mitigate potential clinical toxicities of novel therapeutics such as antibody-drug conjugates (ADC’s) and nanomedicines.

You will have the opportunity to work closely with a team of Scientists to apply ground-breaking technologies and push the boundaries of predictive safety science with our vision in mind: to deliver innovative safety science to help restore oncology patient's lives and eliminate cancer as a cause of death

Additionally, you will:

Work with senior scientists to support experimental studies for discovery safety assessment of new drug candidates.

Apply complex 3D in vitro models such as organoids and micro-physiological systems for safety assessment of new therapeutics.

Assess concerns about organ specific toxicities, non-specific and target mediated clearance and evaluate strategies to overcome these.

Essential Criteria

  • A BSc in cellular biology, pharmacology, immunology, toxicology or similar field
  • Ability to understand biology around novel targets and pathways to drive scientific testing
  • Proven experience in laboratory cellular biology techniques applied to development of physiologically relevant cellular assays to evaluate biological mechanisms (including but not restricted to confocal imaging, primary cell culture and flow cytometry)
  • Strong oral presentation and written communication skills
  • Highly motivated, innovative scientist with a collaborative mentality and a desire to drive personal development.

Desirable Criteria

  • Expertise in the design and execution of cellular experiments to determine the effects of biotherapeutics on biological systems
  • Scientific knowledge of in vitro models of haematopoiesis.
  • Experience with antibody-based therapeutics, including antibody drug conjugates
  • Experience with human/non-human primary cell culture including practical experience with haematopoietic cells.
  • Experience with advanced cell culture systems such as micro-physiological systems
  • Understanding of the drug discovery process from experience in the biotech/pharmaceutical industry or collaborations

At AstraZeneca, we 're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.

So, what’s next?

Complete your application before the below closing date.

This role is open from 06/09/2022 we encourage your application no later than 27/09/2022

Where can I find out more?

Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

Date Posted

06-Sep-2022

Closing Date

27-Sep-2022

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.