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Senior Scientist – Process Chemistry

AstraZeneca UK

Location: Cheshire East

Job Type: Full time


Senior Scientist – Process Chemistry

Location: Macclesfield, UK

Competitive Salary & Benefits

Date Posted: 08.09.22

Pioneer a new future to meet global healthcare challenges

We are committed to leading in sustainability. Backed by a belief in the connection between the health of our business, people and the planet. Be part of shaping a better future for all, supporting healthy communities by addressing the global societal and economic burden of disease. Help to limit our environmental impact by supporting our ambitious sustainability goals. From reducing our operational carbon footprint and waste generation, to driving efficient energy and water usage. And we do it all with ethics and transparency – doing the right thing in all our operations and interactions.


Chemical Development:

In Chemical Development we believe that nothing is impossible, and we are determined to push the boundaries of science to deliver medicines to our patients. We combine people’s technical knowledge and understanding with their talent and drive to design, develop and optimise synthetic routes and processes that deliver the active pharmaceutical ingredients of our medicines in a sustainable, commercially viable way. We believe in innovation and continuous improvement, working closely with colleagues in academia and across industry, to ensure that we apply the newest technologies and principles in the processes we develop.

We have an exciting opportunity for a Senior Scientist to join growing process chemistry development teams.

As a process chemist working closely with analytical chemists, engineers, project managers and other scientists, you will contribute to pharmaceutical development programmes, supporting project progression through late clinical development and launch. You may lead significant parts of chemistry development programmes, directing the work of other scientists.

Key Responsibilities:

  • Design and implementation of new chemical routes and processes suitable for scale-up, with a focus on process understanding

  • Being responsible for optimising chemical manufacturing processes taking consideration of speed, quality, cost, sustainability, reproducibility and efficiency

  • Collaboration with other scientists to contribute to the development of new medicines

  • Assessment and management of process risks arising from scale, equipment or process changes

  • Supporting problem solving when development or manufacturing issues arise

  • Working with third party organisations to develop and manufacture API processes

Essential Requirements:

  • A PhD in Organic Chemistry, or BSc/MSc with relevant industrial experience to an equivalent level

  • Substantial experience in practical organic synthesis

  • Proven record of innovation through, for instance, authorship of papers, inventor status on patents, or presenting at external conferences

  • An excellent understanding of synthetic reagents and methodologies, reaction mechanisms and modern analytical techniques

  • The ability to think innovatively to drive improvement and address issues when contributing to project strategies

Desirable Requirements

  • Lab-based pharmaceutical industry and/or process development experience, using a broad range of practical techniques

  • Practical experience of modern synthetic technologies, e.g. process analytical techniques, continuous processing, high through-put experimentation, etc.

  • A substantial and influential record of publication

  • Proven laboratory team leadership skills

  • The ability to develop and analyse multiple solutions to problems

  • The confidence to mentor and drive performance and development among your peers

Skills and capabilities

  • Ability to challenge and innovate, bringing new solutions and opportunities for chemical development.

  • Ability to analyse and interpret sophisticated chemistry problems and provide solutions

  • Excellent communication skills, with the ability to communicate across interfaces of scientific disciplines, culture, and expertise both internally and externally

  • The ability to confidently participate in, and potentially lead, improvement projects

Please note applications must include your current CV and a covering letter which presents your key areas of strength and why you should be considered for the role.

Closing date: 25.09.22

At AstraZeneca, we 're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.

Date Posted


Closing Date


AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.