Senior Scientist

AstraZeneca UK

Location: Cheshire East

Job Type: Full time


Senior Right Particle PAT Scientist

Location – Macclesfield, UK

Competitive salary and benefits

Opening date – 16th September 2022

Make a more meaningful impact to patients’ lives around the globe

Here you’ll have the opportunity to make a meaningful difference to patients’ lives. With science at its heart, this is the place where breakthroughs born in the lab become transformative medicines – for the world’s most complex diseases. Answer unmet medical needs by pioneering the next wave of science, focusing on outcomes and shaping the patient ecosystem.

With our ground-breaking pipeline, the outlook is bright. Be proud to be part of a place that has achieved so much, yet is still moving forward. There’s no better time to join our global, growing enterprise as we lead the way for healthcare and society.

Chemical Development:

In Chemical Development we believe that nothing is impossible, and we are determined to push the boundaries of science to deliver medicines to our patients. We combine peoples technical knowledge and understanding with their talent and drive to design, develop and optimise synthetic routes that deliver the active pharmaceutical ingredients of our medicines in a sustainable, commercially viable way. We believe in innovation and continuous improvement, working closely with colleagues in academia and across industry, to ensure that we apply the newest technologies and principles in the processes we develop.

We have an open position for a Senior Scientist in our Right Particle Team. The responsibilities and requirements of the position are outlined below.

As a Senior Scientist, you will be a scientific leader in our growing crystallisation and particle engineering community across Chemical Development. Together with teams of colleagues in other departments and skill areas you will design, develop, optimise and scale-up challenging processes to robustly deliver materials with desired physicochemical attributes. You will also plan and drive improvement projects, use new technologies or modify our ways of working within AstraZeneca or externally with our Contract Development and Manufacturing Organisations (CDMOs).

What you’ll do

  • Provide crystallisation expertise in process development, process scale-up and manufacturability for drug substance and intermediates as an integral part of route development.
  • Champion and drive the sustainability of right particle processes with respect to environmental impact, efficiency and cost.
  • Work collaboratively with colleagues in Drug Product Development to identify and define the required particle properties for downstream processing.
  • Championing new and emerging PAT (e.g. FBRM, PVM, Raman, FTIR, NIR etc...) tools to design and develop controlled crystallisations to give particles with desired properties.
  • Applying chemometrics (i.e. multivariate methods and statistics e.g. PCA, MCR, PLSR… etc) to understand chemical interactions in pharmaceutical processes.
  • Deliver Chemistry Manufacturing and Controls (CMC) content and contributions to regulatory filings throughout the clinical development phase and commercial filings.
  • Act as a scientific expert to initiate, drive and deliver science and technology and other improvement projects within and outside Chemical Development.
  • Develop an external network (industrial and academic) to bring learning and innovative crystallisation and particle engineering science into AstraZeneca.
  • Tackle complex scientific problems.
  • Mentor and supervise junior colleagues.

Essential for the role

  • A degree and / or PhD in Chemistry or Chemical Engineering.
  • The ability to support multiple projects as a lead Right Particle scientist.
  • Provide laboratory-based expertise to project teams in the design and development of crystallisation and isolation processes, as an integral part of synthetic route development.
  • Providing expertise in the deployment of PAT tools (e.g. FBRM) for crystallisation, isolation and drying processes.
  • Working knowledge of chemometrics, data handling & image analysis.
  • Experience in a range of particle/materials characterisation techniques.
  • Have the ability to independently represent the department and the Right Particle skill area within multi-functional teams.
  • The ability to work collaboratively with colleagues in a number of Drug Product departments to define desired particle properties for formulations, manufacturability and bioavailability.
  • Generating, reporting and interpreting high quality data with clear impact to development projects.
  • Ability to present information and engage in discussions in multi-disciplinary project teams.
  • Effective communication and influencing skills.
  • Continuously develop yourself and your colleagues via training and shared learning experiences to improve our efficiency and effectiveness
  • Ensuring own work is performed and recorded in accordance with appropriate Safety, Health & Environment (SHE), quality and compliance standards, e.g. Good Manufacturing Practice (GMP)

Desirable for the role

  • Experience of working in the Pharmaceutical or Fine Chemicals Industry.
  • Involvement with working with Contract Development and Manufacturing Organisations (CDMOs)
  • Knowledge of particle size reduction unit operations.
  • Participation in the production of non-crystalline or large molecule New Chemical Entities (NCEs).
  • Some familiarity with modelling software (e.g. Aspen, DynoChem, gPROMS FormulatedProducts) to support process design and understanding.
  • Exposure to technology transfer and commercial production.
  • Experience of leading and driving improvement projects or new ways of working.
  • Collaboration with external partners investigating a new technology or process and implementing these within an industrial setting.

Why AstraZeneca?

At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We’re on an exciting journey to pioneer the future of healthcare.

So, what’s next?

Complete your application before the below closing date.

This role is open from 16th September 2022 and we welcome your application no later than 30th September 2022.

Date Posted


Closing Date


AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

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