Associate Director, Immuno Oncology
Job Type: Full time
We are seeking a highly motivated Associate Director with extensive expertise in preclinical animal modelling in Immuno-oncology (IO) and deep understanding of the regulatory and compliance aspects of in vivo work to join our team in Cambridge, UK.
At AstraZeneca, we turn ideas into life changing medicines. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. We’re passionate about the potential of science to address the unmet needs of patients around the world. We commit to those areas where we believe we can really change the course of medicine and bring big new ideas to life.
AstraZeneca’s vision in Oncology is to push the boundaries of science to change the practice of medicine, transform the lives of patients living with cancer, and to ultimately eliminate cancer as a cause of death. A broad pipeline of next-generation medicines is focused principally on four disease areas - breast, ovarian, lung and haematological cancers.
What you'll do
As an experienced in vivo scientist within the IO Bioscience team, you will play a pivotal role in identifying the next generation of innovative IO therapies, and in deepening our understanding of cancer immunology.
The team delivers key in vivo data to oncology projects across all phases of drug discovery and early development and works with different modalities such as monoclonal and multi-specific antibodies, chemotherapy, radiotherapy, antibody drug conjugates, modified RNA, small molecules, PROTACs, and cell-based therapies. The role will be based at our vibrant R&D site in Cambridge (UK) within AstraZeneca’s state-of-the-art laboratories. At AstraZeneca Early Oncology, we are driven by innovation and our commitment to make a real-life difference in patients’ lives. That difference starts with you.
Main Duties and Responsibilities
Working in this scientific leadership role you will apply your technical and scientific experience to the discovery of innovative immunotherapy approaches for cancer. You will be expected to develop into a project licence holder to support our complex oncology drug discovery portfolio. As the project license holder, you will be responsible for upholding high welfare standards while ensuring delivery of preclinical data to the Early Oncology drug discovery pipeline for a team of in vivo scientists.
You will stay up to date with the latest discoveries in tumour immunology and in vivo modelling, and share your expertise both within and beyond the group, and will monitor changes in the UK regulatory environment.
You will work in a matrix environment, providing expert advice and mentorship. You will cultivate and maintain strong working relationships with a wide range of internal and external partners. You will apply your influencing, coaching and mentoring skills to ensure effective cross-functional working within teams. You may also directly line manage team members, helping to set goals and objectives and coordinating their professional development. Some out-of-hours work on weekends and holidays may be expected.
PhD (or equivalent) in a biological science with 5-10+ years of post-Ph.D research experience in industry or academia. Industry experience is preferred but exceptional candidates with substantial & relevant academic experience will be considered.
Deep expertise in immuno-oncology, plus broad understanding and enthusiasm for translating basic science into novel cancer therapies
At least 5 years’ experience of running and overseeing in vivo models of cancer or immune mediated diseases in support of a broad portfolio of research programs.
Demonstrable experience of maintaining the highest standards of welfare and ethical compliance as well as ensuring the integrity of all generated scientific data.
Previous experience as a Home Office project licence holder or deputising for a project licence holder.
Outstanding team working skills and a proven track record of working collaboratively to ensure scientific quality and rapid progression of projects.
Excellent scientific communication skills including both ability to write reports (e.g. regulatory documents, project licences, and manuscripts) and give oral presentations to broad and diverse audiences.
Line management experience.
General knowledge of biologics drug development. The ability to work closely with key leaders in partner functions to ensure that project goals and timelines are adhered to.
Biology / project leadership experience on large-molecule / antibody drug discovery projects either in industry or biotechnology sector.
Experience working in the field of IO drug discovery
An appreciation 3Rs and alternative preclinical models.
Experience working with successful cross-functional scientific project teams
Authorship of patents, grants and/or publications in top-tier scientific journals
Locations: Cambridge UK
Salary: Competitive + Excellent Benefits
At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We’re on an exciting journey to pioneer the future of healthcare.
So, what’s next?
Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you.
Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it’s yours.
Where can I find out more?
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AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.