Tissue Diagnostics Science Manager
Job Type: Full time
Tissue Diagnostics Science Manager
Join the team dedicated to Oncology, with an ambition to eliminate cancer as a cause of death. It’s our vision that unites and inspires us.
With indications and high-quality molecules at all stages of our pipeline, we keep pushing forward. Fusing ground breaking science with the latest technology to achieve breakthroughs. Backed by investment, we are seeking to deliver 6 new molecular entities by 2025.
A place built on courage, curiosity and collaboration – we make decisions driven by patient outcomes. Empowered to lead at every level, free to ask questions and take sensible risks that write the next chapter for our pipeline and Oncology team.
Pioneers of collaborative research we have built an outstanding scientific community both internally and externally. Fusing academia and industry, we have united some of the world’s foremost medical centres.
Have the opportunity to build an exciting and meaningful career as part of the team committed to improving the lives of millions with cancer.
Precision Medicine and BioSamples within AstraZeneca focuses on matching medicines to those patients who will benefit from them most and delivers companion or complementary diagnostic assays that align with the drug development process and enable personalised healthcare approaches within our clinical portfolio.
In 2022, we have openings within in the Tissue Diagnostics team as part of Precision Medicine. Your scientific area of expertise may relate to one or more of the following:
Clinical Study Operations
Tissue Based Diagnostics (IHC, ISH)
You would be part of multidisciplinary teams implementing and delivering diagnostic tests to match the right patients to the right drugs. Specifically, you'd be:
Delivering diagnostic testing to clinical studies as agreed with project leaders including: diagnostic test establishment in partner laboratories, establish innovative diagnostic tests (e.g. tests relying on machine learning/AI), monitor diagnostic test data for quality control, provide scientific troubleshooting when necessary and preparation of study reports with presentation at appropriate meetings.
Accountable for the operational, scientific and regulatory aspects of establishing and controlling diagnostic tests used to identify patients who are eligible to enter drug clinical trials.
Performing technical due diligence of potential external partners (e.g. start-up companies, diagnostic manufacturers, laboratories) in scientific area(s) of expertise.
Leading projects across internal and external partners in a global multi-disciplinary environment, applying scientific, technical and operational expertise.
Accountable to scout and evaluate emerging technologies in your area of expertise aligned with mid and long term strategic priorities of Precision Medicine.
Find opportunities, propose solutions and work across boundaries in the scientific area(s) of expertise that will enable drug development projects and diagnostics labelling.
Generating scientific evidence from a variety of data-types (e.g. images, real-world evidence, clinical trial data) to enable companion diagnostic test selection, regulatory submissions and diagnostic test life-cycle management.
Delivering diagnostic data work packages to enable regulatory submission and approval inclusive of studies to enable market adoption and life cycle management, including statistical data analysis.
Building and maintaining a knowledge of current and emerging diagnostic technologies in area of expertise.
Accountable for the delivery of scientific evidence enabling the development of new diagnostic tests, their regulatory submissions and commercial launches.
Driving improvement in the scientific area(s) of expertise, aligned to Precision Medicine strategic objectives of increasing project success, making valuable contributions to projects and delivering better medicines to patients.
Being accountable for the time and quality of agreed work.
Providing updates on the progress, risks and opportunities of the agreed work to the appropriate governance bodies for review, challenge and issue resolution.
Taking on small supervisory or skills transfer / training roles
BSc or equivalent experience in relevant subject
Experience of working in collaborative or multi-functional initiatives
Excellent verbal and written communication skills
Knowledge of tissue-based biomarker assays, such as immunohistochemistry (IHC) and/or in situ hybridisation (ISH), including troubleshooting and QC
Operational experience of clinical trial set up, documentation and QC / monitoring of tissue testing
Advance degree or equivalent experience in a relevant area
An understanding of clinical and diagnostic development and commercialisation.
Knowledge of clinical testing procedures and applicable laboratory testing regulations such as Good Clinical Practice, CAP/CLIA, Good Clinical Practice and Quality Systems Regulation.
Why we love it
If your passion is science and you want to be part of a team that makes a bigger impact on patients’ lives, then there’s no better place to be. Here we truly understand science and apply it every day to strengthen and grow our pipeline.
This role can sit at our UK, Cambridge or Poland, Warsaw locations
Competitive Salary & Benefits
Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you.
Where can I find out more?
Our Social Media,
Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/
Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/
Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en
Your Recruiters LinkedIn (Zara Newman) - https://www.linkedin.com/in/zara-newman/
At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and ignite your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We’re on an exciting journey to pioneer the future of healthcare.
So, what’s next:
Are you already envisioning yourself joining our team? Good, because we can’t wait to hear from you!
AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.