Associate Principal Translational Biomarker Scientist

AstraZeneca UK

Location: Cambridgeshire

Job Type: Full time


Associate Principal Translational Biomarker Scientist

Location Cambridge UK

Competitive Salary and Flexible Benefits

Be empowered to be innovative and creative where difference is valued

Join a place built on innovation and creativity. Where different views and perspectives are welcomed and valued. An environment that champions inclusion, and teams that reflect the diversity of the communities that we serve.

It propels each of us forward, harnessing our differences to unlock challenges and bring new solutions. Unleash your curiosity and entrepreneurial spirit to uncover new insights that challenge conventions. Here we are forever pushing the boundaries as we feel comfortable spotting opportunities, making quick decisions and taking smart risks.

Neuroscience at Astrazeneca

With a rich heritage and a research and development focus on specific aspects of neurodegenerative diseases, analgesia and psychiatry, AstraZeneca continues to push the boundaries of science in neuroscience in collaboration with other innovative partners across industry and academia.

Join a small, agile business unit, which runs semi autonomously within AstraZeneca and has a biotech culture, which is continuing to evolve and grow with new products and talent joining year on year!


  • Working productively in a matrix team environment, you'll take ownership of multiple biomarker projects within Neuroscience and serving as the Translational Medicine subject matter expert on biomarker science.

  • Hands-on laboratory research to identify and qualify translational biomarkers for target engagement from early Discovery to early Clinical Development.

  • Conducting laboratory biomarker analysis to deliver data for preclinical and clinical projects.

  • Coordinating methods transfer to external collaborators and Contract Research Organizations (CROs) and monitor assay performance at CROs.

  • In collaboration with Biology and Clinical, select the most appropriate biomarker methodology for project decision making, whether single biomarkers or multi-omics approaches to identify biomarker signatures.

  • Working closely with bioinformaticians in Data Science and AI / Quantitative Biology to extract knowledge from large omics datasets.

  • Applying biomarkers to support quantitative PK/PD methods to enable translation from preclinical research to clinical development, including dose selection in clinical trials working with DMPK and Clinical Pharmacology groups.

  • Providing input on biological sampling and biomarker assays in pre-clinical and clinical protocols, Investigator’s Brochure and regulatory documents.

Essential requirements

  • Education: Ph.D. in pharmacology, biochemistry, immunology, pharmaceutical science or biological sciences.

  • Experience: post-doctoral/industry experience in biomarker research and development. Publication record demonstrating excellent scientific credentials.

  • Excellent hands-on laboratory skills and experience in the development of biomarker assays for research or clinical use

  • Good knowledge of regulatory guidelines on biomarkers and bioanalytical assays.

  • Track record of successful implementation of immunoassays, multi-omics (e.g. proteomics, transcriptomics) and cell-based assays (e.g. flow cytometry) for biomarker discovery using nonclinical or clinical samples.

  • Strong expertise in immunoassay development and qualification.

  • Experience with working in cross-functional teams.

  • Organisational skills with attention to detail and demonstrated ability to write technical reports, biomarker protocols, perform quantitative analyses and present data.

  • Excellent inter-personal, collaboration and communication skills (written and verbal).


  • Neuroscience training and experience in academia or industry, particularly in chronic pain or neurodegeneration

  • Bioinformatics skills including application of biological pathways' analysis for biomarker identification

At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.

So, what’s next?

Complete your application before the below closing date.

This role is open from 24th October 2022, and we welcome your application no later than 6th November 2022.

Where can I find out more?

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Neuroscience at AZ:

Date Posted


Closing Date


AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

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