Senior Scientist - Protein Scientist

AstraZeneca UK

Location: Cambridgeshire

Job Type: Full time


Do you have a passion for antibody discovery and protein sciences? Would you like to be part of delivering our next-generation biotherapeutics portfolio in the Oncology therapeutic area in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!

About AstraZeneca

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies!

Fast-paced, it takes agility and responsiveness to stay committed in our pursuit of excellence. We work with focus to seek the unanswered questions – innovating, challenging accepted norms, quick decision-making and taking smart risks. A place of trust, it’s an opportunity to take accountability, be brave, speak up, step up and redefine Oncology, now and in the future. Be a part of improving lives. This is the time to join the team who is confident that cures for cancer are within our grasp.

In this role, you will support antibody discovery and protein sciences to deliver our next-generation biotherapeutics portfolio in the Oncology therapeutic area, focusing on Tumour Targeted Delivery. In this role, you will craft, lead and conduct laboratory projects/experiments, develop methods, and generate, interpret, and report scientific data. You will also contribute to identifying and developing ground-breaking technologies that benefit biologics drug discovery and have a proven track record of creatively solving scientific challenges.

What you'll do

  • Design, express and purify antibodies and proteins to enable therapeutic biologics drugs projects in Oncology and BioPharma R&D. The particular focus of the work will be on Antibody Drug Conjugates (ADCs), RadioImmuno Conjugates (RICs), and other antibody/protein-based therapeutics.

  • Contribute to multi-disciplinary research drug discovery/technology project teams, effectively communicating forward-looking recommendations and contributing to project team decisions based on their findings, the findings of others, and factors from outside the company

  • Establish internal networks and collaborations within scientific field of value to the business and present data at internal (intra- and inter-departmental) meetings

  • Demonstrate solid interpersonal communication by establishing good working relationships with team and department members and others within the company

Essential Skills and Qualifications:

  • PhD with relevant experience or BSc/higher degree with equivalent lab-based experience

  • Solid experience of designing and producing engineered protein constructs with a deep understanding of structure-function relationships

  • Strong technical skills in molecular biology, cell culture, biochemistry, and protein expression and purification

  • Expertise in bacterial and mammalian expression systems, AKTA-GE purification systems, and protein characterization techniques.

  • Excellent communication, capable of developing good working relationships with individuals across organizational boundaries, and experience working within a team environment

Desirable Skills and Qualifications:

  • Background in drug discovery and development in the pharmaceutical industry

  • Experience in antibody engineering, next-generation biologics development for oncology, e.g., multi-specific mAbs and ADCs/RICs

  • Experience in bioconjugation

  • Experience with in-vitro biochemical characterisation assays, such as SPR (Biacore) or BLI (Octet), and functional cell-based assays

  • Experience with stable cell line generation

Why AstraZeneca?

At AstraZeneca, we 're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We’re on an exciting journey to pioneer the future of healthcare.

So, what’s next?

Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you.

Competitive salary package and benefits

Open Date: 11/11/2022

Close Date: 30/11/2022

Where can I find out more?

Our Social Media:

Follow AstraZeneca on LinkedIn

Follow AstraZeneca on Facebook

Follow AstraZeneca on Instagram

Date Posted


Closing Date


AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

You’ve got this!