Senior Scientist Bioscience Immunology, Early Respiratory and Immunology

AstraZeneca UK

Location: Cambridgeshire

Job Type: Full time

Posted


Diverse Minds. Go further with bold new opportunities Collaborate with diverse minds

Collaborate in an inclusive environment, a place full of bold new opportunities. And in return… we’re looking for people who are open and respectful, ambitious and driven.

Who we are

Passion, determination and resilience is in our DNA. That’s why we always step up, never afraid to learn from our failures.

What we do

In our work we aim to bring wider benefits to society – building healthy communities and limiting our impact on the planet. We are committed to leading the quest to meet rising global demand for effective healthcare.

How we do it

Safe to share and learn from each other – ours is an inclusive environment. Where difference is recognised and uniqueness is valued.

AstraZeneca is a global, science-driven biopharmaceutical company. We are dedicated to discovering, developing, and delivering innovative, meaningful medicines and healthcare solutions that enrich the lives of patients. The vision of AstraZeneca Early Respiratory & Immunology (Early R&I) is centered on delivering life-changing products that advance world health and help fight and cure disease. Early R&I is one of three main therapeutic research areas within AstraZeneca that deliver candidate drugs into late-stage clinical development. Here, you’ll have the opportunity to make a difference in people’s lives every day.

As a part of building Immunology Bioscience team within Early R&I department, we are seeking a highly motivated senior researcher with a strong understanding of adaptive and/or innate immunity and ideally understanding key biological pathways in immune-mediated diseases such as rheumatological and/or gastrointestinal diseases. The role will be based in Cambridge (UK) within AstraZeneca’s state-of-the-art laboratories where you will follow the science to help drive innovation and advance medicine to help improve patient lives.

In this role, you would be expected to demonstrate an exceptionally high level of enthusiasm for innovative scientific research leading to the discovery and development of novel therapeutics. Ideally, you have expertise in T-, B- and innate immunity and/or pathogenic mechanisms involved in tissue pathology in immune-mediated diseases. Experience in complex co-culture systems, cell imaging or precision immunology technologies, and an ability to apply this experience to an understanding of the basic mechanisms of human immune-mediated disease is preferred.

Main Duties and Responsibilities:

In this role you will be a biology leader in the Bioscience, Immunology team focusing on developing therapeutics for treatment of Rheumatological and Gastrointestinal Diseases. This job includes senior lab-based responsibilities, and you will have significant opportunity to drive the direction of the work. The work will be predominantly human in vitro systems, working with primary and disease tissue-derived cells, although knowledge and experience of in vivo science is preferred. Knowledge and experience with Precision Immunology strategies such as multi-modal single-cell technologies and systems immunology is a bonus. A background in human immunology and immune-mediated diseases and translational approaches to understand basic biological mechanisms in disease is needed.

  • You will focus your research on characterizing novel immunological pathways in health and disease to aid target validation and drug projects

  • You will contribute and drive strategies for new target identification for the treatment of immune-mediated diseases such as rheumatological and gastrointestinal diseases

  • You will collaborate with scientists from a variety of functional teams in Cambridge (UK) and with our sites in Gaithersburg (US) and Gothenburg (Sweden).

  • You will benefit from daily interaction and collaboration with highly accomplished scientists and the position offers a unique opportunity to work in a dynamic and innovative environment developing your career at the interface of research and drug discovery.

  • You will be involved in the development of new assays and Implementing novel technical advances with human tissue cultures.

  • Encouragement and support will be provided to help the individual develop specialist knowledge and skill sets.

  • Publication of your work in high impact journals.


Requirements:

  • Ph.D. in Immunology, or a closely related field

  • Expertise in drug discovery projects in the immunology or a closely related field of biology is preferred

  • Highly organized and self-motivated, with the ability to work independently as well as collaboratively within a team to conduct a high-level research project.

  • Strong hands-on skills in basic in cell biology, biochemical and molecular techniques.

  • Expertise in primary human cell culture, including co-culture models, ex-vivo functional assays, expertise in multi-panel FACS and/or mass cytometry (CyTOF), including both intracellular and extracellular cell surface markers are essential.

  • Experience with precision immunology strategies, including multi-modal single-cell technologies (i.e. single-cell RNAseq, spatial transcriptomic) is a strong plus.

  • In vivo skills and association with in vivo models of autoimmunity and inflammation are preferred.

  • Strong written and oral communication skills and the ability to critically analyse data sets

  • Demonstrated ability to run collaborative efforts and utilize external resources to find the most effective solutions to drug discovery problems

At AstraZeneca, we 're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, sex, gender, gender expression, sexual orientation, age, marital status, veteran status, or disability status. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.


So, what’s next?

Are you already imagining yourself joining us? Good, because we can’t wait to hear from you!

Date Posted

17-Jan-2023

Closing Date

31-Jan-2023

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

You’ve got this!