Senior Scientist – In vitro display platforms, Biologics Engineering, Oncology R&D
Job Type: Full time
Do you have expertise in, and passion for therapeutic antibody discovery using in vitro display platforms? Would you like to apply your expertise to impact the next generation biotherapeutics portfolio in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!
At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.
Welcome to Granta Park, Cambridge (UK), one of over 400 sites here at AstraZeneca, providing a collaborative environment where everyone feels comfortable and able to be themselves is at the core of AstraZeneca’s priorities. It’s important to us that you bring your full self to work every day. To help you maintain your best self, here’s a sneak peek into some of the things this site provides for you…Cambridge is one of the most exciting bioscience hotspots in the world and plays a central role in our mission to deliver life-changing medicines to patients. Granta Park has a gym, nursery, and central restaurant/coffee place as part of the science park facilities that are accessible to our staff. We also have our own bistro and deli in the AZ buildings. There are regular lunch & learn events including running clubs and after work socials on the last Friday of every month. This is our biggest and most spacious lab site with easy access from all major routes and ample car parking available - come and join us! Please be aware that towards the end of 2023 you will be required to move to our new state of the art Cambridge Biomedical Centre.
In the Oncology Business Unit, we relentlessly follow the science, challenging the status quo to deliver more effective treatments to patients in need. Our dedication means we purposefully push back the limits of knowledge to change the practice of medicine. To ensure no patient is left behind, no matter what stage of disease. The Biologics Engineering team is responsible for the discovery and optimisation of biological candidate drugs to support all therapy area drug discovery pipelines and for the development of in-house biologics discovery platforms and novel drug modalities to support future drug discovery efforts. Fast-paced, it takes agility and responsiveness to stay committed in our pursuit of excellence.
What you'll do
We are seeking a highly motivated Senior Scientist to help support our therapeutic discovery pipeline as well as develop and implement our next-generation antibody libraries and screening methods in their application to pre-clinical programs. The successful candidate will add to our team of multidisciplinary and passionate scientists excited by research at the interface between technology and biology. He/she will be a well-organized and a highly productive bench scientist that can design and execute experiments efficiently, as well as analyse, interpret and present data. The role entailsthe isolation and optimisation of biologics for our therapeutic programmes using a range of in vitro display platforms (e.g. phage, yeast, mammalian and ribosome display) as well as supporting technology development and innovation programs within the Biologics Engineering group.
A Ph.D level scientist with post-doctoral experience, or Batchelor’s degree with equivalent experience in molecular biology, screening and sequencing
Strong hands-on experience in molecular biology methods and technologies (e.g., PCR, RT-PCR, cloning (ligation-dependent and independent methods), site-directed mutagenesis, Sanger sequencing/analysis), ideally applied to generation of antibody fragment (or other protein scaffold) libraries
Extensive experience and track-record working with in vitro display technologies (e.g., phage, yeast, mammalian and ribosome display, etc.) applied to antibody isolation and optimisation – library generation and bio-panning using different enrichment strategies
Ability to independently design, execute and manage diverse antibody isolation campaigns and fit-for-purpose engineering strategies
Ability to optimize protocols, troubleshoot, interpret experimental results/data and maintain accurate, high quality and up-to-date experimental records
Good understanding of antibody genetics and experience with analysis of antibody repertoires – germline annotation, clustering and diversity analysis
Strong communication skills in a team environment and an ability to learn and embrace new technologies quickly
Experience with development of antibody-drug conjugates (ADCs) and/or radionuclide antibody conjugates (RACs)
Experience in designing and generation of synthetic antibody/scaffold libraries
Experience with next-generation sequencing (NGS) applied to antibody discovery
Experience in high-throughput antibody screening, reformatting and characterisation methods including in vitro biochemical assays (ELISA, SPR, BLI or flow cytometry) and functional assays
Experience with computational methods and machine learning applied to antibody design and optimisation
Experience with leading/co-leading and/or managing research projects
Experience with managing or supervising people
Competitive salary & benefits
Close date: 12/02/2023
At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together. Interested? Come and join our journey.
So, what’s next!
Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available, and we hope it’s yours.
Where can I find out more?
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AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.