Senior Scientist Protein Engineer, Biologics Engineering, Oncology R&D

AstraZeneca UK

Location: Cambridgeshire

Job Type: Full time


Do you have expertise in antibody engineering and passion for therapeutic antibody discovery? Would you like to apply your expertise to impact the next generation biotherapeutics portfolio in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!

About AstraZeneca

At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.

Site description

Granta Park, Cambridge (UK), is one of over 400 sites here at AstraZeneca, providing an environment where everyone feels comfortable and able to be themselves is at the core of AstraZeneca’s priorities, it’s important to us that you bring your full self to work every day. To help you maintain your best self, here’s a sneak peek into some of the things this site provides for you…Cambridge is one of the most exciting bioscience hotspots in the world and plays a central role in our mission to deliver life-changing medicines to patients. Granta Park has a gym, nursery, and central restaurant/coffee place as part of the science park facilities that are accessible to our staff. We also have our own bistro and deli in the AZ buildings. This is our biggest and most spacious lab site with easy access from all major routes and ample car parking available - come and join us! Please be aware that during the second half of 2023 you will be required to move to our new pioneering Cambridge Biomedical Centre.

Business area

The Biologics Engineering team is responsible for the discovery and optimisation of biological candidate drugs to support all therapy area drug discovery pipelines and for the development of in-house biologics discovery platforms and novel drug modalities to support future drug discovery efforts.

Fast-paced, it takes agility and responsiveness to stay committed in our pursuit of excellence. We work with focus to seek the unanswered questions – innovating, challenging accepted norms, quick decision-making and taking smart risks. A place of trust, it’s an opportunity to take accountability, be brave, speak up, step up and redefine Biologics Engineering, now and in the future. Be a part of improving lives.

What you'll do

We are seeking a highly motivated Senior Scientist to support our biologics discovery pipeline and provide protein engineering and production expertise to support the discovery of next-generation biologics. This role will support the development and implementation of next-generation in vitro antibody discovery platforms, which can be applied to pre-clinical programs. The role includes the production of protein therapeutics, predominantly antibodies and involves the development and running of automated processes. The role also requires a detailed understanding of in vitro antibody discovery techniques as well as the analysis and interpretation of antibody NGS data and involves working as part of a multi-disciplinary team, and close working with other AstraZeneca departments (e.g., Biology, Data Science & Artificial Intelligence, and IT).

Essential for the role

  • PhD with relevant experience or BSc/higher degree with equivalent lab-based experience

  • Hands-on experience of applying principles, theories and techniques used in cloning, expression & purification of protein biologics, to support drug and technology projects

  • Track-record of development of new or improved high throughput protein expression processes, including IVTT, and mammalian systems, as well as the use of high-throughput automated systems

  • Excellent understanding of the theoretical concepts of protein:protein interactions and applying these to experimental design in support of drug and technology projects

  • Ability to provide solutions to a variety of complex problems

  • Ability to optimize protocols, troubleshoot, interpret experimental results/data and maintain accurate, high quality and up-to-date experimental records

  • Strong communication skills in a team environment and an ability to quickly learn and embrace new technologies

Desirable for the role

  • Experienced in molecular biology methods and technologies (e.g., PCR, RT-PCR, NGS), and their application to the generation of antibody fragment (or other protein scaffold) libraries

  • Experience in high-throughput antibody screening, reformatting and characterisation methods including in vitro biochemical assays (ELISA, SPR, BLI or flow cytometry) and functional assays

  • Experience with computational methods and machine learning applied to antibody/protein design and optimisation

  • Background in drug discovery and development in the pharmaceutical industry

  • Experience of leading/co-leading and/or managing research projects

Why AstraZeneca?

At AstraZeneca, we 're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We’re on an exciting journey to pioneer the future of healthcare.

So, what’s next?

  • Are you already considering joining the team? Good, because we can’t wait to hear from you.

  • Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available, and we hope it’s yours.

  • If you’re curious to know more please get in touch with Louise Bennett

Competitive salary package and benefits

Close Date: 12/02/2023

Where can I find out more?

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Date Posted


Closing Date


AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

You’ve got this!