Senior Medical Director, Cardiovascular Disease, Early Clinical Development

AstraZeneca UK

Location: Cambridgeshire

Job Type: Full time

Posted


Senior Medical Director, Cardiovascular Disease, Early Clinical Development

Location: Central Cambridge, UK

Competitive salary and benefits on offer

Are you an experienced physician with clinical expertise in the management of patients with atherosclerosis, dyslipidemia, and heart failure and do you have well-developed clinical research experience? Would you like to be part of a hardworking and successful team, who are translating meticulous scientific discoveries into early phase clinical development plans and studies across a wide range of diseases?

At AstraZeneca, we’re dedicated to being a Great Place to Work with a inclusive and diverse team of dedicated colleagues who work in a trusting, and collaborative work environment. We are dedicated to improving the health care and quality of life for patients across a wide range of diseases and disorders by developing therapies that address unmet clinical needs and that provide clinicians with novel evidence-based treatment options that enable them to optimise the care of their patients.

Who We Are

In the Cardiovascular, Renal & Metabolism (CVRM) Early Clinical Development team, we are investigating the drivers of CVRM disease progression through ground breaking methods and data-driven drug discovery approaches. In this context, we are investigating a wide range of drug modalities from our rich CVRM portfolio of compounds across cardiovascular diseases, dyslipidemia, and heart failure patient populations.

Early Clinical Development (ECD), part of the Early CVRM organisation, is where science meets clinical drug development with a focus upon delivering innovative, early phase clinical studies and accelerating human target validation while collaborating closely with our late phase clinical development and regulatory colleagues who guide our pivotal phase 3 clinical studies. We are a team with varied strengths of experienced physicians, clinical scientists, and clinical program directors who collaborate to delineate early phase clinical development strategies, craft innovative phase I-IIb clinical trials, develop and validate novel surrogate endpoints, and translate scientific ideas to proof of concept studies in targeted patient populations.

We are recruiting a Senior Medical Director Physician, passionate about Cardiovascular Disease, Dyslipidemia, and Heart Failure. In this role, you will have the opportunity to work at the forefront of early clinical and translational research within CVRM. In a multidisciplinary environment, you will play a key role in progressing a rich and diverse pipeline of both small and large molecules in numerous active clinical programs. This is an office-based role that is located at AstraZeneca’s R&D site in Cambridge in the United Kingdom.

What you’ll do

You will be responsible for managing and contributing to early phase I-IIb global clinical trials and related clinical research projects for compounds that are targeting cardiovascular disease, dyslipidemia, and heart failure, as well as serving as an expert on the design, conduct, monitoring, data interpretation, and reporting of these studies. Additionally, you will work on cross-functional teams within our ECD group and across the broader early CVRM organisation that are framing our strategies and development plans for compounds that are targeting major metabolic disorders, such as Diabetes Mellitus, Obesity, and NASH, given that these disorders intersect with cardiovascular disease, dyslipidemia, and heart failure, and influence disease progression.

In this role, you will contribute to cross-functional project teams with professionals from a diverse range of geographic locations. We will rely on you to:

  • Contribute to the design and implementation of early-stage clinical projects and ensure that all clinical programs under your purview are scientifically rigorous, are clinically sound and valid, are operationally successful, and adhere to Good Clinical Practice and regulatory requirements
  • Collaborate closely with groups within the early CVRM therapeutic area to provide expert clinical input into pre-clinical scientific activities such as target selection, lead generation and optimisation, clinical pharmacology, in vivo animal studies, in vitro studies, and drug formulation and manufacturing
  • Work with a highly capable team of physicians and scientists who design scientifically thorough, innovative, and efficient early phase clinical study protocols that are aligned with the pre-clinical scientific findings and clinical development plans for each compound, while ensuring seamless transition of early clinical programs to late stage development
  • Contribute to our interactions with regulatory authorities and governmental research organisations in the United Kingdom and European Union related to our early phase clinical programs and studies
  • Assist with the preparation of various official and regulatory documents for Regulatory Authorities and other agencies, such as Dossiers, CTAs, INDs, Safety, and annual reports
  • Contribute to our efforts to certify and validate the scientific evidence for non-clinical, surrogate endpoints used in our early phase cardiovascular clinical studies including imaging, digital, and biomarker endpoints
  • Serve as an internal and external scientific expert to communicate and disseminate the scientific accomplishments of our early clinical development team through internal workshops and forums, presentations at scientific meetings, and scientific publications
  • Contribute to our interactions with key external clinical and scientific experts for cardiovascular disease, dyslipidemia, and heart failure and translate input from external advisors into our clinical development plans, scientific discovery efforts, and regulatory interactions
  • Contribute to our ongoing efforts to improve, enhance, and evolve the operational planning and execution of our early phase cardiovascular clinical studies, including developing innovative approaches for engaging and supporting clinical trial sites in the United Kingdom and other European countries to perform well in our early phase clinical studies

Essential for the role

We believe that you are a Medical Doctor, who has well-established clinical expertise in the treatment of cardiovascular disease, dyslipidemia, and heart failure, with a minimum of 7-10 years of clinical research experience either in the academic research environment or in the pharmaceutical/biotechnology industry. You will need to have well-developed interpersonal skills as well as a highly collaborative approach to the work that we do, including:

  • A robust clinical research experience and scientific publication record
  • Early phase clinical translational research expertise, including experience in designing, monitoring, performing and interpreting early phase clinical trials and solid knowledge of biomarkers, surrogate endpoints, biostatistics, and safety reporting

Why AstraZeneca?

Here, we need leadership at every level – Physicians who not only have expertise, but also the ability to build a case, engage multiple partners, and communicate effectively with different audiences. With that kind of remit comes great responsibility. We truly believe that everyone contributes with an outstanding set of competence. Your curiosity and passion for personal development combined with support from colleagues, mentors and leaders, will ensure you improve your skills, abilities and contribution. We offer competitive salary and excellent benefits, such as extra paid Holiday, Private Medical Benefits, On-site exercise and much, much more.

So, what’s next?

Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you.

Welcome to apply!

Where can I find out more?

AstraZeneca Cambridge: https://www.astrazeneca.com/our-company/our-locations/cambridge.html

CVRM at AstraZeneca: https://www.astrazeneca.com/our-therapy-areas/cardiovascular-renal-and-metabolism.html

Life at AstraZeneca : https://careers.astrazeneca.com/inclusion-diversity

Recent Publications: https://www.astrazeneca.com/publication.htm

Date role opened: 4th January 2023

Date role closed for applications: 28th February 2023

Date Posted

06-Jan-2023

Closing Date

28-Feb-2023

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

You’ve got this!