Modelling and Simulation Expert - BioPharmaceutics
Location: Cheshire East
Job Type: Full time
Modelling and Simulation Expert - BioPharmaceutics
Macclesfield - UK
Competitive Salary & Benefits
Date Posted: 05.01.23
Make a more meaningful impact to patients’ lives around the globe
Here you’ll have the opportunity to make a meaningful difference to patients’ lives. With science at its heart, this is the place where breakthroughs born in the lab become transformative medicines – for the world’s most complex diseases. Answer unmet medical needs by pioneering the next wave of science, focusing on outcomes and shaping the patient ecosystem.
Business area – New Modalities and Parenteral Development (NMPD)
To meet patients’ needs, AstraZeneca recognises the opportunity to apply a diverse range of new modality technologies to design novel therapeutics. This is exemplified by the increased number of new modalities entering clinical development.The New Modalities and Parenteral Development department (NMPD) has accountability for developing the pipeline of both new modality projects and traditional synthetic molecules requiring parenteral delivery.
It sits within the Pharmaceutical Technology and Development (PT&D) function. PT&D is the bridge which turns brilliant science into effective medicines. We work across the entire value chain, designing and delivering the active ingredients, formulations and devices required to support new and existing medicinesthat help millions of people.
An exciting opportunity has arisen for a specialist in BioPharmaceutics modelling and simulationto join our Pharmaceutics capability in NMPD, Macclesfield, UK, at the Associate Principal Scientist level.
In NMPD, you will be an influential member of a group responsible for generatingdeep BioPharmaceuticsunderstanding of drug products including conventional dosage forms, enabling formulations, nano-medicines and advanced drug delivery technologies across multiple delivery routes.We will rely on you to provideexpertBioPharmaceuticsknowledge,and apply sophisticated modelling and simulation approaches, in orderto build mechanistic understanding of drug product performance and design bridging strategies.Combined with your experience, the resulting insights will be used to support drug projects from the early clinical phase through to commercial filings.
As an Associate Principal Scientist, you will be encouraged to work collaboratively with colleagues from other disciplines in AstraZeneca (e.g.modelling, formulation, materials science, analytical, clinical pharmacology, regulatory etc) and with external partners (e.g.academics, professional organisations, technology providers etc) to deliverboth drug product and strategic capability projects. The scope of the opportunitywill require you to lead and mentor others whilst applying your expertise to potentially new challenges such as sub-cutaneous delivery. You will also be an importantlink to our modelling and simulation group, working with them to develop new modelling tools and approaches by combining your BioPharmaceutics and modellingskills.
This role would suit an individual who can blend technical expertise and scientific passion with a committed and collaborative approach to delivery. All role accountabilities have a significant impact on the development of AstraZeneca’s project portfolio and the continuous development of our scientific prowess. Depending on the ability and experience of the successful applicant, coaching and training will be provided to ensure optimal delivery against the role.
Required Skills & Knowledge
Degreein a relevant subject leading tosignificant industrial or academic experience of applyingmodelling and simulation solutions to BioPharmaceutic problems,through the use ofPhysiologically-basedBioPharmaceutic modelling (PBBM)with tools such as GastroPlus, SimCyp etc.
Excellentunderstanding of the relationship between in-vitro drug product properties and in-vivo pharmacokinetic performance, ideally with knowledge of the link to control strategy development
The ability to research andsolve stretching scientific problems and undertake troubleshooting of project issues, with clear examples of the use of modelling and simulation
Communication and engagement skills that enable discussion of complex ideas in an easy to understand way, to a range of stakeholders
Experience of technical coaching, supervision of small teams or leading scientific projects.
Be empowered to be innovative and creative where difference is valued
In NMPD and AstraZeneca, we're dedicated to being a Great Place to Work, where you are empowered to push the boundaries of science and fuel your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. We have an inclusive culture that fosters diversity and collaboration and are committed to lifelong learning, growth and development.
So, what’s next…
Are you ready to bring new ideas and fresh thinking to the table? Excellent! We can’t wait to hear from you! Please note applications must be made before the closing date below and include your current CV and a cover letter.
Close Date: 29th January 2023
AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.