Analytical Scientist, Physicochemical Development

AstraZeneca UK

Location: Cambridgeshire

Job Type: Full time


R-156383: Analytical Scientist, Physicochemical Development

Location: Cambridge, UK

Competitive salary with excellent benefits

At AstraZeneca, we turn ideas into life changing medicines. Working here means being action-oriented, thinking big and working together to make the impossible a reality!

AZ’s Analytical Sciences team

Analytical Sciences operates in a highly cross disciplinary environment that plays a crucial role in advancing new biopharmaceutical drug projects through the clinic. Central to our work is the detailed characterisation of our protein therapeutics that is achieved through using a wide variety of analytical techniques. With an aspiration to find innovative therapeutics to address unmet medical needs, we support an ever-expanding set of molecular formats from monoclonal antibodies, bispecifics, ADCs, fusion proteins, peptides and viruses.

We are currently recruiting for a dedicated Analytical Scientist to join our team with experience in analytical methods and a good understanding of biochemistry methods. This is an outstanding opportunity to join a growing team within a vibrant environment, motivated by our shared purpose – to deliver life-changing medicines to patients.

What you’ll do

You’ll play an important role in drug development programmes by supporting the analytical development of novel proteins and novel biotherapeutics.

Key activities include, but are not limited to:

  • Supporting and managing analytical testing using a variety of techniques including chromatography and mass spectrometry to assess the quality of AstraZeneca’s biological products, supporting product release, characterisation, formulation and process development
  • Undertaking sample preparation for a variety of analytical testing and studies, incl. forced degradation studies and high throughput automation workflows
  • Aiding method development for chromatography and LC-MS methods
  • Assisting and managing analytical-related aspects of programs (including protocol and report preparation, data generation, data reviews, trending and tracking, presenting data to other team members) whilst consistently meeting high quality standards

Essential Criteria

  • BSc / Masters, or equivalent in Biochemistry or a related field
  • Practical experience with analytical methods and an understanding of biochemistry methods in protein characterisation, including, for example HPLC/UPLC (IEX, RP), CE, LC-MS and peptide mapping techniques, glycosylation characterisation techniques, higher order structure techniques (CD, FTIR)
  • A pro-active, outstanding communicator
  • Effective organisational and planning skills with the ability to look ahead whilst remaining flexible and agile to the changing needs of the business
  • Highly capable of collaboration and working to tight deadlines and exacting standards
  • Excellent attention to detail and the ability to maintain accurate and timely records of all work performed within the laboratories

Desirable Criteria

  • Experience of / familiarity with any of the following software packages: OpenLab, BioPharma finder, PMI, UNIFY, Empower, GraphPad
  • Familiarity with LC-MS methods
  • Knowledge of automation platforms

*** We will be reviewing applications and shortlisting on a rolling basis - as such we reserve the right to withdraw this vacancy ahead of the stated closing date ***

Why AstraZeneca?

Make a more meaningful impact to patients’ lives around the globe.

With science at its heart, this is where breakthroughs born in the lab become transformative medicines – for the world’s most complex diseases. Answer unmet medical needs by pioneering the next wave of science, focusing on outcomes and shaping the patient ecosystem.

We’re dedicated to being a Great Place to Work

Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.

So, what’s next?

This advert will be running from Thursday, 19th January and, we welcome your application as soon as possible. The scheduled closing date is Sunday, 5th February 2023.

Where can I find out more?

This is what we’re made of:
Our sustainability ambition:
Recent Publications:

Date Posted


Closing Date


AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

You’ve got this!