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Senior Scientist, Chemistry (ADCs)

AstraZeneca UK

Location: Greater London

Job Type: Full time


Do you have expertise in, and passion for, Research in Chemistry? Would you like to apply your expertise to design studies, develop, validate methodology to regulatory standards to determine quality and stability of drug substances and products; in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!


AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies. Join the team dedicated to Oncology, with an ambition to eliminate cancer as a cause of death. It’s our big vision that unites and inspires us.

With multiple indications and high-quality molecules at all stages of our innovative pipeline, we keep pushing forward. Fusing cutting-edge science with the latest technology to achieve breakthroughs. Backed by investment, we are aiming to deliver 6 new molecular entities by 2025.


Our Spirogen site, part of the AstraZeneca Group - Whitechapel, London… one of over 400 sites here at AstraZeneca, providing a collaborative environment where everyone feels comfortable and able to be themselves is at the core of AstraZeneca’s priorities, it’s important to us that you bring your full self to work every day. To help you maintain your best self, here’s a sneak peek into some of the things this site provides for you After-work events, Lunch & Learns, Bright and spacious balanced office working environment, Networking events. Situated in the heart of London’s historical east end close to the vibrant and fashionable areas of Shoreditch, Spitalfields and Brick Lane with excellent public transport links to central London.


Fulfilling our ambition to be world leaders in Oncology. We are already the fastest growing team within AstraZeneca and across the industry, and there are countless new indications and targets in our game-changing pipeline. We deliver this value through launch excellence, commercial efficiency and improving the lifecycle. By leveraging our commercialised portfolio we are confident we can change the practice of medicine and redefine cancer treatment.

What you’ll do

As a Senior Scientist you'll be fully proficient in your own research area within a chemistry subject area. Design studies, develop, validate methodology to regulatory standards to determine quality and stability of drug substances and products. Working independently, with the ability to advise/train/nurture less experienced scientists.

As part of the group you will work on the design, synthesis and characterisation of novel drug payload molecules and warheads, for antibody conjugation and biological evaluation.

  • Apply technical knowledge and expertise to achieve project targets in a timely fashion and to agreed quality standards

  • Develop and maintains a level of scientific knowledge and capability, perhaps extending to specialist expertise in a specific area of Chemistry

  • Represents specialism on relevant projects teams, ensuring the provision of appropriate and timely data to the team

  • Independently, designs and carries out analytical studies and experiments that require knowledge, and develops and validates appropriate test methodology and specifications to achieve project aims

  • Independently, assesses and reports data with a clear understanding of its reliability, interprets findings and draws authoritative conclusions and recommendations so that their significance can be appreciated

  • Provides training /guidance to junior scientists on technical and functional processes

  • Helps to develop new and innovative techniques and methodologies and draws up relevant investigations

  • Generates CMC (chemistry, manufacturing and control) documents, plans, protocols and reports ensuring that the project objectives are met and work is of the highest standard

  • Liaises with colleagues from other subject areas with the purpose of discussing project-related matters, sharing experiences and reporting progress

  • Leads operational aspects of the transfer of methodology to AZ manufacturing operations and/or contract laboratories

  • Contributes to the management of external collaborations, e.g. consultants and contract research organisations

  • Uses own expertise to input into management decisions about channelling resources to reduce risk associated with inappropriate investment decisions

  • Develops own scientific competence by staying ahead of relevant scientific developments, by collaborating with peer scientists or through contacts with external organizations

  • Ensures that work is performed in accordance with appropriate Safety, Health & Environment (SHE), quality and compliance standards, e.g. Good Laboratory Practice (GLP)

Essential for the role

  • Ph. D. in Chemistry with postdoc experience or equivalent and relevant experience within the subject area

  • Understanding of current principles and concepts in Chemistry

  • Understanding of regulations and relevant compliance systems related to own area of work

  • General understanding of other Discovery / R&D Subject areas and their role in achieving the objectives of research area

  • Understanding of patent and IP issues

Competitive salary & benefits

Close date: 27/01/2023

Why AstraZeneca?

At AstraZeneca, we 're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. A culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We’re on an exciting journey to pioneer the future of healthcare.

So, what’s next?

  • Are you already considering joining the team? Good, because we can’t wait to hear from you.

  • Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available, and we hope it’s yours.

  • If you’re curious to know more; please get in touch with Louise Bennett.

Where can I find out more?

Our Social Media, Follow AstraZeneca on LinkedIn

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Date Posted


Closing Date


AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.