Senior Separation Scientist - Chemical Development

AstraZeneca UK

Location: Cheshire East

Job Type: Full time


Senior Separation Scientist - Chemical Development

Macclesfield, UK

Competitive Salary & Benefits

Date Posted: 24.01.23

Be part of shaping the future of Operations here at AstraZeneca

Be part of shaping the next phase of Operations’ journey towards the 2025 strategy! Build on our foundations of high performance through agility, responsiveness, reliability and efficiency to deliver our new modalities and complex pipeline to market at speed. Backed by a supportive team, be part of accelerating our operational excellence with innovations in cutting-edge science, Lean ways of working and fast changing digital technologies!

Pharmaceutical Technology & Development:

Pharmaceutical Technology and Development (PT&D) are the bridge, which turns brilliant science into medicines that help millions of people. We work across the entire value chain, designing and delivering active ingredients, formulations and devices required to support new medicines – from supplies for use in early toxicology studies and clinical trials to developing the technology to ensure drugs can be scaled up for commercial manufacture.

We are growing our Chemical Development group in PT&D, and we are looking for a strong Separation Scientist to join a vibrant team that is working on the next generation of medicines and play a key role in the development of new medicinal products. As a Senior Scientist you will be responsible for supporting and leading aspects of our separation science strategy including training, capital, external and internal collaborations and new technology introduction. You will also be responsible for carrying out close support and collaboration with project leads on Separation Science activities including development, validation and transfer of methods.

These responsibilities will be across all aspects of separation science but will concentrate on the development of efficient and data rich chromatographic methods that support all of the PT&D Chemical Development project submissions across the small and large molecule portfolio.

As part of a global company with a focus on developing its people, you will have the opportunity to develop both personally and professionally while helping to deliver innovative medicines across the globe.

Other responsibilities include:

  • Collaborating with project scientists in providing separation science expertise and excellence into projects to develop, validate, transfer and troubleshoot chromatographic methods.

  • Using lean to drive continual improvement across the training & capability of other scientist’s, chromatographic processes, instrument robustness, performance and utilisation.

  • Developing and implementing new sustainable platform approaches and workflows that deliver new chromatographic methods for our small molecule portfolio and new modalities.

  • Using chromatographic data sources to simplify and accelerate chromatographic modelling, simulation and critical decision making.

  • Growing internal and external collaborations.

  • Working with AZ Partner Organisations to ensure our instrument management systems and procedures are in compliance.

All these activities will have a significant impact on driving and developing Separation Science Strategy in PT&D. The role, therefore, has a significant impact on project delivery and scientific reputational aspects of the business.


  • BSc/PhD level education in a relevant discipline and related experience working within a separation science environment.

  • Application and understanding of key separation science analytical techniques including Liquid, Gas, Supercritical Fluid and Ion Chromatography alongside relevant detection techniques.

  • Fundamental knowledge of separation science with a track record developing and troubleshooting chromatographic methods.

  • Experience of technical supervision, coaching and mentoring.

  • A good understanding of the principles and management of SHE and cGMP.

  • Understanding of the required CMC content or contributions to regulatory filings throughout the life cycle of process especially where it relates to separation science.

Skills & Capabilities:

  • Good interpersonal skills and able to communicate a scientific principle or idea.

  • Good team working and networking skills.

  • Strong fundamental and practical knowledge of separation science techniques.

  • Influencing and prioritisation skills to ensure delivery of key activities.

  • Willingness to try new ideas and drive the science.

  • Lean problem solving skills.

  • Good understanding in the application of chromatographic modelling software.

  • Proficient use of statistics to understand data.

At AstraZeneca, we 're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.

So, what’s next?

Complete your application before the below closing date. Please ensure that you include your CV and a Covering Letter in your application highlighting your suitability and motivations in applying to the position.

Date Posted


Closing Date


AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

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