Senior Scientist – Peptide Chemistry

Full time
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AstraZeneca UK
Healthcare & medical
10,001+ employees
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Senior Scientist – Peptide Chemistry

Cambridge UK

Competitive salary & benefits

About AstraZeneca

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies. At AstraZeneca, we are pioneering new frontiers by identifying and treating patients earlier, working towards the aim of eliminating cancer as a cause of death.

The role

AstraZeneca are currently seeking a skilled and enthusiastic peptide chemist to join our dynamic Peptide Discovery team. Situated at the Discovery Centre in Cambridge, you will be part of a chemistry team developing the next generation of peptide medicines.

As a peptide chemist, you will be responsible for the design and chemical synthesis of therapeutic peptides and reagents. We are looking for someone who has a good understanding and background in solid-phase synthesis to support delivery of our peptide portfolio. In this laboratory-based position, you will be responsible for multi-step synthesis, purification and analytical characterisation of complex peptides. You will work independently within research teams and also with internal or external collaborators. This role requires a strong background in peptide chemistry, excellent problem-solving skills and the ability to work in a fast-paced, collaborative environment.

As part of a growing team, you will benefit from numerous personal and professional development opportunities at AstraZeneca!

Key responsibilities

  • Independently plan and implement sophisticated experimental work
  • Design and synthesize peptides using solid-phase peptide synthesis (SPPS) techniques, using both automated peptide synthesisers and manual procedures
  • Troubleshoot and resolve synthetic and analytical challenges
  • Cleavage of peptides from resin supports, purification by preparative HPLC and analysis using mass spectrometry techniques
  • Contribute to multi-disciplinary research and drug development
  • Communicate results to global project teams and partners
  • Maintain accurate and detailed experimental records and results
  • Stay current with advancements in peptide chemistry and related fields

Essential experience

  • Postgraduate qualification (or equivalent) in Chemistry, Biochemistry or relevant subject area
  • Deep understanding of chemistry and peptide chemistry
  • Technical proficiency in solid-phase and/or peptide synthesis via manual syntheses or automated peptide synthesisers
  • Familiarity and working knowledge of HPLC purification and mass spectrometry
  • Excellent record-keeping and strong written and verbal communication skills
  • Experience of working within a team environment and developing good working relationships with individuals across organisational boundaries

Desirable for the role

  • PhD (or Masters degree with equivalent lab-based experience)
  • Skills in rational/ computational design of peptides
  • Previous experience within the pharmaceutical industry
  • Experience of working with peptide conjugates or bioconjugation techniques
  • Background knowledge in cancer biology

Why AstraZeneca

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognizing their potential. Join us on our journey of building a new kind of organization to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening new ways to work, pioneering methods and bringing unexpected teams together. Interested? Come and join our journey!

AZ Cambridge

An exciting bioscience hotspot, Cambridge is home to one of AstraZeneca’s three strategic, global R&D Centres, alongside Gothenburg and Gaithersburg. Over 3,600 employees work from our various sites across Cambridge and our offices are internationally renowned for attracting high performers, including several Nobel prize winners.

Currently based in our brand new R&D facility, which was officially un-veiled in November 2021, by His Royal Highness, The Prince of Wales.

The Discovery Centre (DISC), located at the heart of the Cambridge Biomedical Campus, is designed to play a central role in our mission to deliver life-changing medicines to patients. As our largest research and development centre in the UK, it has more than 2,000 people working across therapy areas and drug discovery and development once fully occupied.

Find out more about our Cambridge campus and the DISC, here:

We encourage your application before the 23rd July 2024.

Date Posted


Closing Date

23-Jul-2024Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.