Job Title: Senior Scientist, Translational PKPD

Location: Cambridge UK

Do you have expertise in Oncology, and a passion for PKPD modeling and DMPK science, applied to Cancer biology? Would you like to apply your expertise to impact the lives of patients in a company that follows the science and turns ideas into life changing medicines?

As a Senior Scientist/Associate Director in Translational PKPD, you will have the opportunity to drive strategy and provide global leadership in DMPK science on Antibody Drug Conjugates (ADCs), Radioconjugates (RCs) large molecules. Your role will involve providing projects with DMPK support, exploring the PK/PD/Efficacy relationships in pre-clinical models, using these models to build a quantitative understanding of the dose & schedule requirements for therapeutic intervention across different patient populations as a single agent and combined with other agents.

Essential for the role:

• Representing the Translational PKPD group and providing overall scientific leadership for cross functional and external collaborations involving DMPK.

• Exploring the effects on target and pathway to understand the requirements for efficacy and set a candidate drug target profile (CDTP).

• Predicting human dose and regimen together with providing input into exposure and pharmacodynamic (PD) biomarker based decision criteria for early clinical trials.

• Driving learnings through back translation of early clinical exposure and PD data and providing prioritized future options for clinical testing.

• Leading and participating in Oncology strategic scientific initiatives and continuous improvement projects by providing expert DMPK knowledge and participating in the development of Discovery or Development strategies in PKPD.

• Working collaboratively and in continuity with other partner functions.

• Having a breadth of influence and impact across AstraZeneca Clinical Pharmacology and externally within their discipline.
  

Minimum Requirements:

• University Degree in a discipline with a significant component of analysis and quantitation, such as pharmaceutical sciences, quantitative pharmacology, pharmacometrics, engineering, physics, or applied mathematics.

• Relevant industry experience in DMPK/preclinical/translational project-facing role within pharmaceutical R&D.

• Excellent interpersonal and communication skills coupled with strong influence and leadership skills.

• Specialist in tools such as WinNonLin/Phoenix NLME, R, SimCYP , NonMem, Berkeley Madonna and MATLAB.

• Track record of supporting PK, PKPD and TKPD aspects of projects, with a delivery focus and ability to meet timelines to prespecified quality and cost.

• Track record of demonstrating strong publication record demonstrating comprehensive understanding of DMPK and pharmacology/safety aspects of drug discovery and development
  

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Ready to make an impact? Apply now and join us on this exciting journey!

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