Senior Scientist / Associate Principal Scientist – Formulation

Location: Macclesfield, UK

Salary & Benefits Competitive

Meaningful Impact. Make a more meaningful contribution Impact patients’ lives every day

Make a more meaningful impact in your career, with greater ownership and accountability to contribute. And in return we’re looking for people driven by making a difference to patients and society, dedicated to doing the right thing.

Do you have an extensive background in drug product development? Are you passionate about formulation science and can you envision applying your expertise to positively impact the development of new medicines? Join us to push the boundaries of science!

What we do

AstraZeneca is a global, science-driven biopharmaceutical company dedicated to discovering, developing, and delivering innovative, significant medicines and healthcare solutions that enrich the lives of patients.

Pharmaceutical Sciences is a CMC organisation working in the Early Portfolio and accountable for the design and development of synthetic routes, preclinical and phase I/II formulations, encompassing both small molecules and new modalities, across the whole range of AstraZeneca´s therapeutic areas.

We are looking for an enthusiastic and highly capable Senior Scientist / Associate Principal Scientist to join our Early Product Development and Manufacturing (EPDM) team in Macclesfield, UK. The teams are focused on the development of small molecule drug products to support projects in the early clinical phases. As a Formulation Scientist in EPDM, you will be responsible for supporting the design of drug delivery systems for clinical studies. You will work closely with analytical, manufacturing, biopharmaceutics, and solid-state scientists in EPDM as well as external partners to ensure all the goals are met.

Main Duties and Responsibilities:

• Drive scientific product design, process and/or product performance understanding to influence strategies in early product development with line of sight to the late-stage development

• Plan/Perform pre-formulation studies of APIs based on the available preclinical data to develop a strategy for clinical dosage forms

• Formulate APIs into conventional and enabling dosage forms for oral administration

• In-depth knowledge to characterize physical attributes of APIs and formulated dosage forms

• Demonstrate scientific leadership for formulation area and deliver improvements through coaching and mentoring of others individually and through the skill area networks

• Plan/conduct the experimental work either in-house or together with the CMOs to achieve efficient products ready for scale-up to clinic

• A strong presence in the laboratory, acting as a role model for other team members

• Anticipate, identify and mitigate/tackle potential formulation project issues

• Track record of authoring high quality regulatory submissions for IND/IMPD

• support the science and innovation improvements within EPDM

• Ensures own work is performed in accordance with appropriate Safety, Health & Environment (SHE), quality and compliance standards

• Support the technical development of other scientists

• Keep abreast with the scientific literature and proactively apply existing and novel approaches to projects

• Publish novel work in peer reviewed journals

Qualifications and Experience:

• Degree (preferably Masters or PhD) in Pharmaceutical Sciences or a related subject

• Leader and is at forefront in the scientific field of formulation

• Strong background of formulating and characterising a variety of dosage forms, for example, conventional immediate release tablets and capsules, amorphous solid dispersions, nanoparticles and lipid-based delivery systems

• Experience in formulation and process development of poorly soluble molecules

• Experience in management of outsourced activities at CMOs

• Track record as a scientific leader, providing scientific challenge and direction to colleagues

• In depth understanding of how the physicochemical and solid-state properties of the drug, dosage form and route of administration affect the rate and extent of absorption

• Experience in building mechanistic understanding of the drug delivery system performance in vitro and linking it to in vivo performance

• Experienced in developing and applying predictive tools to aid product design

Skills and Capabilities:

• Consistent record of problem solving and hands-on experience from years in the laboratory working on the development of dosage forms for early clinical studies

• Ability to handle several projects at the same time, using initiative and creativity to meet agreed objectives and timelines

• Be visible and accessible - be the ‘go-to’ person in their area of expertise

• Ability to mentor peers for enhanced individual and team performance and development

• A track record of establishing mutual respect, trust, and close collaborations with internal and external organizations, and the ability to interact effectively at all levels

• Global mentality and ability to work across multiple geographical locations.

• Demonstrate a high degree of personal credibility

• A track record of publishing in peer reviewed journals

Next Steps – Apply today!

To be considered for this exciting opportunity, please complete the full application on our website. If you know someone who would be a great fit, please share this posting with them.

This role is open from 12/07/2022, we welcome with your application no later than 05/08/2022

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.

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Date Posted

Closing Date

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.