Senior Scientist in Translational Pathology – Image analysis, Oncology

We are seeking a Senior Scientist to join the Translational Pathology group in Oncology R&D Translational Medicine department, where you will be at the forefront of the evolution of translational science for the global oncology group in AstraZeneca!

You will have the opportunity to impact an industry-leading portfolio of programs from early clinical development of novel therapeutics through to post-marketing opportunities that support approved targeted therapies.

AstraZeneca

At AstraZeneca, we work together across global boundaries to make an impact and find answers to challenges. We do this with the utmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people’s exceptional skills with those of people from all over the globe!

Major Responsibilities and Accountabilities:

In this role you will need to use the best available science and technology to develop new image analysis solutions to measure biomarkers in clinical tissues as well as using data science techniques to provide insight into the results. Using these techniques you will generate disease linkage data to guide indication selection and targeted patient populations, as well as measuring drug target engagement. This work will inform clinical decisions for selecting therapeutically relevant doses and schedules, as well as building our understanding of key cancer pathway interactions to guide rational drug combinations.

Skills and experience:

• PhD plus at least 2 years experience in industry/ a relevant field.
• Knowledge in one or more AZ portfolio areas: tumour drivers and resistance, DNA damage response (DDR), immuno-oncology (IO) and antibody drug conjugates (ADC).
• Skilled in digital image analysis.
• Experience in development and validation of biomarker assays.
• Experience in manual or automated immunohistochemistry (brightfield or fluorescence).
• Ability to lead from the bench in problem solving and the development of innovative solutions.
• Peer-reviewed publications in the field of translational pathology or cancer biology.

Desirable– Although training will be given, experience in the following areas would provide a distinct advantage

• Expertise in one or more AZ portfolio areas, including related biology and knowledge of translational approaches to developing therapeutics for cancer.
• Experience with HALO and Visiopharm image analysis softwares
• Experience working with human tissues and tissue-based histopathology methods.
• Experience of conducting studies for Good Clinical Practice (GCP).
• Skills in developing multiplexed immunohistochemistry or in situ hybridization (ISH) assays.
• Career exposure to the pharmaceutical industry and the drug development process.

Location:Cambridge, UK

Competitive salary and benefits package on offer.

So, what’s next?

• Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you, apply today!.

Date Posted

Closing Date

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.