Biotransformation Senior Scientist, DMPK Oncology R&D

Do you feel passionate about the possibilities of science to change lives? Do you have a background in biotransformation science and a drive to deliver data that directly impacts drug discovery projects? If so, this may be the role for you.We currently have an exciting opportunity for a highly motivated biotransformation scientist to join our expanding Oncology DMPK team.

AstraZeneca

AstraZeneca is a global biopharmaceutical company driven by what science can do. We are dedicated to discovering, developing, and delivering innovative, meaningful medicines and healthcare solutions that enrich the lives of patients. Oncology R&D is a major focus area and growth platform at AstraZeneca. Our vision is to be at the forefront of developing the new generation of cancer therapies. We work together across all boundaries to have a positive impact in the world.

Oncology DMPK department

The Oncology Drug Metabolism and Pharmacokinetics (DMPK) department provides ADME/PK, as well as translational PK/PD Modeling & Simulation support to all modalities in our discovery and development portfolio.

Be part of fulfilling our ambition to be world leaders in Oncology. We are already the fastest growing team within AstraZeneca and across the industry, and there are countless new indications and targets in our game-changing pipeline. We deliver this value through launch excellence, commercial effectiveness and maximising the lifecycle. By leveraging our commercialised portfolio we are confident we can change the practice of medicine and redefine cancer treatment.

We’re brave disruptors – entrepreneurial, courageous and pioneering in our approach. Here you have the opportunity to step up, take personal accountability and lead changes in our ever-evolving environment.

What you’ll do

You will join a global biotransformation teamthat provides disciplinary scientific leadership and supports our diverseportfolio including small molecules, PROTACs, antibody drugs conjugates (ADCs) andnano-medicines. . The qualified candidate will work alongside with our DMPK team in Boston (US), maintaining close collaboration within the global department. The position is based in Cambridge UK.

Accountabilities

• Delivering biotransformation studies to assess metabolic pathways of molecules including soft-spot identification, structural elucidation of metabolites and assessment of bioactivation.

• Delivering high quality in vitro/in vivo biotransformation studies to support drug candidate selection, regulatory submissions and MIST.

• Supportingradio-labelled metabolite profiling studies from in vitro and in vivo samples (pre-clinical and clinical mass balance studies) in collaboration with outsourcing partners

• Participating in validating cutting-edge analytical methodologies to support this core function.

• Authoring technical reports, peer-reviewed publications and oral presentations.

Minimum Requirements – Education, Experienceand Capabilities

• PhD in Analytical Chemistry/Biochemistry/Biology/Pharmacology or related area and several years of experience as biotransformation / Met-ID / analyticalscientistor alternatively a first degree and extensive relevant additional experience as biotransformation / Met-ID / analytical scientist.

Extensive experience and expertisein several of the following:

• Structural elucidation of metabolites through the generation and interpretation of high resolution mass spectra and UV spectra and being a speaking partner to the NMR specialists.

• Experience of working with Thermo scientific FT orbitrap mass spectrometers (Q-Exactive, Orbitrap Fusion) would be advantageous.

• Understanding of the mechanisms of P-450 oxidations/reactive metabolites and how this may affect structural compound design

• Ability to design and ideally conductin-vitro experiments for Met-ID studies

• Understanding of how metabolite identification studies are carried out in early drug development (e.g. MIST guideline)

• Work with project teams and external partners to ensure excellent study design and timely reporting of high quality biotransformation studies.

• Scientific publication track record in biotransformation / analytical sciences

• Excellent interpersonal skills that lead to successful collaborative work-relationships

Location: Cambridge,UK

Cambridge Site location

Welcome to Cambridge, one of over 400 sites here at AstraZeneca, providing a collaborative environment where everyone feels comfortable and able to be themselves is at the core of AstraZeneca’s priorities, it’s important to us that you bring your full self to work every day. To help you maintain your best self, here’s a sneak peek into some of the things this site provides for you…

Where life meets Science…Chesterford Research Park offers advanced laboratory and office space set within 250 acres of idyllic parkland near Cambridge – modern, dynamic, flexible facilities perfectly appointed for biotechnology, pharmaceutical and R&D companies. You will have access to a stylish, fully air conditioned health and fitness centre, an onsite restaurant, Lunch & Learn development activities, all within a spacious environment while utilising the most advanced technology.