Senior Scientist – Analytical Chemistry

Location: Macclesfield

Salary: Competitive Salary & Benefits

Date Posted: 02.09.22

Make a positive impact, in a team where it means more

In Operations, we have a big ambition – to deliver more medicines to patients, quicker and more affordably. Backed by the investment, leadership and a clear plan to get there, we bring personal dedication and out of the box thinking!

We are driven by our dedication to deliver accelerated growth for AstraZeneca and to make people’s lives better. It pushes us to keep building on our foundations and progressing as we turn our ever-growing and increasingly complex pipeline from molecule to medicine. Be part of evolving how we work with Lean, cutting-edge science, digitalisation and sustainable practices.

Pharmaceutical Technology and Development (PT&D) are the bridge, which turns brilliant science into medicines that help millions of people. We work across the entire value chain, designing and delivering active ingredients, formulations and devices required to support new medicines – from supplies for use in early toxicology studies and clinical trials to developing the technology to ensure drugs can be scaled up for commercial manufacture.

We are an expanding group looking for strong analytical scientists to join a vibrant team that is working on the next generation of medicines and play a key role in the analytical development of new medicinal products. You will be responsible for using science and innovation to deliver analytical knowledge that encompasses understanding of manufacturing processes, control strategy and robustness during the development of early through to late stage products. You will be able to work independently and lead interactions within cross functional teams, including with Process Chemists, Engineers, Contract Manufacturing Organisations (CMOs), Product Development, Regulatory CMC, Quality Assurance and Supply Chain.

We now have an exciting opportunity for a Senior Scientist in our growing analytical chemistry development teams!

As part of a global company with a focus on developing its people, you will have the opportunity to develop both personally and professionally while helping to deliver innovative medicines across the globe.

As an analytical chemist working closely with process chemists, engineers, project managers and other scientists, you will contribute to pharmaceutical development programmes, supporting project progression through late clinical development and launch. You may lead significant parts of chemistry development programmes, directing the work of other scientists.

Key Responsibilities:

• Leading API analytical activities to support project progression from clinical development phases through to late development and commercialisation

• The development of API analytical control strategies, keeping a strong focus on quality for our patients

• Identifying and solving potential analytical project issues

• Planning and conducting lab-based experimental work in accordance with project timelines

• Collaborating with internal and external manufacturing partners to deliver the analytical aspects of GMP API manufacture

• Keeping abreast of scientific developments and proactively applying existing and novel approaches to projects

• Authoring the CMC components of regulatory submissions and preparation of successful regulatory responses

• Supporting the technical development of other scientists

Required Qualifications, Skills, Knowledge and Experience:

• A degree (BSc, MSc or equivalent) in Chemistry or Analytical Chemistry with a proven track record of analytical development in a pharmaceutical environment, or a PhD including aspects of analytical measurement

• Knowledge and practical experience across a range of analytical techniques, eg LC, MS, GC, NMR including method development and validation

• Scientific leadership skills and the ability to use knowledge and experience to assess options available and deliver robust scientific contributions to projects

• Strong problem-solving skills, underpinned by strong practical laboratory experience

• Experience of working collaboratively within a mixed skill technical team and ability to develop and utilise networks

• Ability to communicate sophisticated scientific information in a clear, concise, and understandable way

• Knowledge and practical experience of quality and regulatory requirements (GMP and ICH) and health and safety requirements

Desirable Skills, Knowledge and Experience:

• Ability to expertly and optimally lead improvement projects

• Strong influencing, planning and prioritisation skills to ensure project delivery to deadlines

• Experience of leading technical teams, mentor and people development

• Dedication to improvement and innovation and knowledge of Lean principles

At AstraZeneca, we 're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.

How to Apply

To be considered for this exciting opportunity, please complete the full application form on our website. Applications must include your current CV and a covering letter, which presents your motivation for applying and suitability for the role.

Application Closing Date: 19th September 2022

Date Posted

Closing Date

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.