12 Month Oncology DMPK- Industrial Student Placement
Job Type: Full time
12-Month Industrial Placement with the Oncology DMPK Team
Locations: Cambridge (UK)
At AstraZeneca every one of our employees makes a difference to patient lives every day. We work together across global boundaries to have impact and find answers to challenges. We do this with integrity even in the most difficult situations because we are committed to doing the right thing.
We are looking to recruit for a 12 Month Industrial Placement Student with the Oncology DMPK Team in Cambridge (UK). The placement will focus on developing and driving mechanistic understanding of the clearance, distribution and drug-drug interactions within the oncology portfolio to ensure that our compounds have the correct properties to enable the appropriate balance between efficacy and safety that will lead to a new medicine.
The placement will involve undertaking a wide range of in vitro ADME studies (absorption, distribution, metabolism, elimination) to understand the metabolism, pharmacokinetics, tissue distribution and physico-chemical properties of molecules from the early discovery portfolio to clinical candidates and our marketed drugs. It will include training in the use of mass spectrometry for bioanalytical quantification and structural identification. The successful placement student will work in a matrix environment interacting with colleagues from the UK and US from multiple disciplines. There will also be the opportunity to learn about ADME properties of what is called "new modalities" like PROTACs (Proteolysis Targeting Chimeras) or ADCs (Antibody Drug Conjugates). These are exciting areas where we need to develop understanding of how the properties of these molecules impact their ADME behaviour and subsequently their behaviour in the clinic.
Key Objectives of the Placement:
- Learn and perform in-vitro experiments to investigate the ADME properties of drug candidates and report results back to the DMPK project lead.
- Design and carry out studies to understand the mechanisms of metabolism and disposition of drug candidates.
- Conduct a bespoke set of studies relating to a DMPK portfolio issue as a stand-alone piece of research which could potentially lead to a publication.
Essential Candidate Requirements:
A degree in a Biological or Chemical discipline is ideal, with the opportunity to spend 1 year in industry starting in September 2023.
Some knowledge of DMPK is desirable but not essential and a desire to learn about DMPK science. All the training on the different assays and associated analytical technologies such as mass spectrometry will be provided by the oncology DMPK ADME Team.
How to Apply
If you are interested in applying for this role please click and apply online providing answers to all of the questions.
Closing Date for Applications: October 16th, 2022 with interviews expected to take place on October 27th, 2022 and October 28th, 2022.
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for the roles without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.
AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.