Head of Clinical Development – Neuroscience

AstraZeneca UK

Location: Cambridgeshire

Job Type: Full time


Head of Clinical Development – Neuroscience

Location: Cambridge

Competitive salary and flexible benefits

Diverse Minds. Bold Disruptors. Meaningful Impact.

AstraZeneca is a global, innovation-driven BioPharmaceutical business that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious disease. But we’re more than one of the world’s leading pharmaceutical companies.

Fast-paced and collaborative, this is a science-led organisation, regardless of the role you provide. It’s not every career that offers the chance to make a lasting impact on the human race and, as one our three strategic hubs, AstraZeneca UK is well positioned for scientific excellence and collaboration.

It takes resilience to embody our entrepreneurial spirit. For those who thrive on experimentation, you’ll get to work with knowns and unknowns. Exploring without limits!

What we’re looking for

In this hands-on, head of clinical development, physician role within neuroscience we are looking for a creative physician who can bring their experience to lead a team of physicians and take ownership for the clinical development of the neuroscience portfolio of large and small molecules.

We look for entrepreneurial thinking and the ability to provide medical leadership to defined operating procedures, and includes study design and execution, development of clinical protocols, medical monitoring, and timely reporting of study outcomes. If this sounds like you, then please apply now!

Neuroscience at Astrazeneca

With a rich heritage and a research and development focus on specific aspects of neurodegenerative diseases, analgesia and psychiatry, AstraZeneca continues to push the boundaries of science in neuroscience in collaboration with other innovative partners across industry and academia.

Join a small, agile business unit, which runs semi autonomously within AstraZeneca and has a biotech culture, which is continuing to evolve and grow with new products and talent joining year on year!

Role accountabilities:

As a member of the Neuroscience team, you will lead the conduct of a portfolio of projects in neuroscience including:

  • Leadership of development, including plans and approach to the projects, ensuring efficient execution and delivery from candidate to end of Phase 2, including contribution to preclinical development enabling first-in-human (FIH) studies.

  • Leadership and personal growth of a team and function.

  • Represent the clinical and medical aspects of neuroscience assets to governance committees and work with colleagues in the late-stage development organization and with co-development partners to facilitate transition of products into pivotal trials.

  • Medical and scientific contribution into design and implementation of clinical protocols, data collection systems (eCRF and related platforms), digital tools, data analysis including the statistical analysis plan.

  • Accountable for planning, conducting and evaluating clinical trials and supervising cross functional team members to ensure successful trial delivery.

  • Review and interpret study results. Analyze and synthesize clinical data for publication, and international regulatory filings. Author clinical publications or provide input into communication and publication development.

  • Establishing close collaboration between company experts.

  • Support assets transitioning from the pre-clinical portfolio into clinical development, with a key role in defining the early clinical development.

  • Selection and management of collaborators and vendors including academic groups, CROs, and technical expertise or services within AZ.

  • Contribute to development of disease area strategies that integrate discovery research with clinical approaches to proof-of-concept in appropriate patient segments.

  • Evaluate and recommend licensing and acquisition opportunities and participate in due diligence activities.

  • Actively participate in co-partnering discussions providing your expertise to joint steering committees and/or clinical co-development teams.

Essential criteria

  • MD, MBBS, MBChB qualification, or equivalent.

  • Significant experience of leadership in a commercial environment is crucial, most likely achieved within the setting of a pharmaceutical company, biotech or contract research organisation.

  • Proven track record of medical proficiencies and decision-making capabilities achieved in a clinical practice setting (at least to the level of senior resident or consultant/attending physician in a relevant medical speciality).

  • Excellent communicator and collaborative team leader.

  • Handle complexity - you will integrate and analyse non-clinical and clinical data as well as data/input from multiple internal and external functional areas. Synthesis of previous clinical data and ongoing medical safety data is required. Capacity to manage multiple tasks/programs with competing deadlines/priorities is essential.

  • Able to operate relatively independently in medical, safety and clinical development tasks with minimal supervision. Once direction is provided, must identify the challenges, generate solutions (or options) and either implement a recovery plan, or advance through relevant functions for further advice.

Why AstraZeneca

At AstraZeneca, we 're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.

So, what’s next?

Complete your application before the below closing date.

This role is open from 11th October 2022, and we welcome your application no later than 11th November 2022.

We will review and interview candidates as they apply.

Where can I find out more?

Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

AZ Cambridge https://www.astrazeneca.com/our-company/our-locations/cambridge.html

Neuroscience at AZ: https://www.astrazeneca.com/our-therapy-areas/neuroscience.html

Date Posted


Closing Date


AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

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