Senior Scientist, In Vitro Metabolism Biology

Location: Cambridge, UK

Competitive salary and benefits

Do you have in vitro expertise within metabolic disease biology and enjoy working in the lab? Would you like to apply your expertise in a global company that is accelerating innovative science and turn ideas into life changing medicines? Join us to discover future treatments for Cardiovascular, Renal and Metabolic diseases!

At AstraZeneca, we work at the groundbreaking of science to develop the ground-breaking medicines of the future – here we do things that have never been done before. We put patients first and strive to meet their unmet needs worldwide.

CVRM is one of three main therapeutic research areas within AstraZeneca. Early CVRM has a patient-centric approach for discovering novel treatments for patients with cardiovascular, chronic kidney and metabolic disease and delivers candidate drugs into late-stage clinical development.

In the Bioscience Metabolism department, we focus on identifying and validating new drug targets for treatment of patients with metabolic disease , as well as evaluating pharmacological aspects, e.g. efficacy and mechanism of action, of potential new drug candidates. The in vitro team delivers key data to projects across all phases of the drug discovery and development process, and we work with different modalities such as small molecules, modified mRNA, antibodies, cell therapy, antisense oligonucleotides and peptides.

We are now recruiting a Senior Scientist with expertise in metabolic disease to join the Bioscience Metabolism in vitro team within the Cardiovascular, Renal and Metabolism (CVRM) therapeutic area at AstraZeneca in Cambridge, UK.

What you’ll do

As a Senior Scientist, you will play a key role in driving science and projects forward within the metabolism bioscience area. This is a lab based role where you will explore novel drug targets with key in vitro data. Collaboration is critical for successful delivery of drug projects and you will work closely with scientists/teams from a wide range of different functions within AstraZeneca as well as with external partners and collaborators. You will work with in vitro biology using cell lines, primary cell and ex vivo models along with molecular and functional biology techniques. You will have the opportunity to try novel techniques and ideas required for progressing existing portfolio and novel science. Responsibilities include:

• Independently design, develop and run in vitro studies and assays for target identification and validation
• Work with molecular biology methods, imaging and cell based functional assays
• Contribute to communications of scientific findings through publications in scientific journals and at meetings
• Proactively contribute to a vibrant and innovative working environment where improvements and new ideas are adopted and freely shared

Essential for the role

• PhD or master’s degree in biology, pharmacology, or equivalent experience in metabolic disease or similar
• Strong experience in cell and molecular biology, biochemistry, in vitro pharmacology, and relevant in vitro/ex vivo assays within the metabolic disease area
• Experience in handling and manipulating relevant cell line, primary cells, human and animal tissue types
• Excellent English communication skills, both spoken and in writing

Desirable for the role

• Significant Experience with in one or more of liver, gut, brain, muscle or adipose tissue biology
• Background in drug discovery and development in the pharmaceutical industry

So, what’s next?

Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you!

For more information about the position please contact David Hornigold + 44 7917 178907.

Welcome with your application no later than January 10, 2023

Cambridge is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.

You will be offered a competitive salary and excellent benefits, such as extra paid Holiday, Private Medical Benefits, On-site exercise and much, much more.

Next Steps – Apply today!

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity. If you know someone who would be an excellent fit, please share this posting with them.

Where can I find out more?

• Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/
• Follow us on Facebook https://www.facebook.com/astrazenecacareers/
• Follow us on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

Date Posted

Closing Date

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.