Senior Scientist Translational PKPD Modeling & DMPK (Oncology)

AstraZeneca UK

Location: Cambridgeshire

Job Type: Full time


The Oncology DMPK department provides drug metabolism & pharmacokinetic, as well as translational PKPD modeling & simulation support to our portfolio.

Be part of fulfilling our ambition to be world leaders in Oncology. We are already the fastest growing team within AstraZeneca and across the industry, and there are countless new indications and targets in our game-changing pipeline. We deliver this value through launch excellence, commercial effectiveness and maximising the lifecycle. By leveraging our commercialised portfolio we are confident we can change the practice of medicine and redefine cancer treatment.

We’re brave disruptors – entrepreneurial, courageous and pioneering in our approach. Here you have the opportunity to step up, take personal accountability and lead changes in our ever-evolving environment.

What You’ll Do

As a Senior Scientist Translational PKPD Modeling & DMPK you will have the opportunity to drive strategy and provide global leadership in PKPD science across our diverse portfolio, and act as role model, mentoring and guiding less experienced members of the team.

Your day-to-day role is to provide projects with specialist modeling input into exploring the PK/PD/Efficacy in pre-clinical models, and using these models in order to iteratively build an understanding of the dose & schedule requirements for therapeutic intervention across different patient populations as a single agent and combined with other agents.

Essential for the role

  • Representing Oncology DMPK and providing overall scientific leadership for cross functional and external collaborations involving DMPK.

  • Exploring the effects on target and pathway to understand the requirements for efficacy and set a candidate drug target profile (CDTP).

  • Predicting human dose and regimen together with providing input into exposure and pharmacodynamic (PD) biomarker based decision criteria for early clinical trials.

  • Driving learning through back translation of early clinical exposure and PD data and providing prioritized future options for clinical testing.

  • Leading and participating in Oncology strategic scientific initiatives and continuous improvement projects by providing expert M&S knowledge.

  • Having a breadth of influence and impact across AstraZeneca DMPK and externally within their discipline.

  • Identifying, championing and developing new ideas.

  • Leading scientific discipline networks and acting as a focus for debate within the AstraZeneca scientific community.

  • Advising on and participating in the development of Discovery or Development strategies in PKPD.

  • Managing student and Post Doc programmes.

  • Leading external collaborative projects with academic or cross-pharma pre-competitive groups.

  • Providing disciplinary scientific leadership and presenting work through patents, publications and lectures.

Minimum Requirements:

  • PhD or equivalent degree in a discipline with a significant component of Modeling & Simulation, such as systems biology, quantitative pharmacology, pharmacometrics, chemical engineering, physics, pharmaceutical sciences or applied mathematics.

  • Relevant industry experience in Modeling & Simulation, ideally in preclinical/translational setting with a focus on small molecules, or a MS degree with proven industry experience.

  • Experience in a project-facing role within pharmaceutical R&D.

  • Comprehensive understanding of DMPK and pharmacology/safety aspects of drug discovery and development with a strong publication record.

  • Track record of supporting PK, PKPD and TKPD aspects of projects, with a delivery focus and ability to meet timelines to pre-specified quality and cost.

  • Specialist in tools such as WinNonLin/Phoenix NLME, NonMem, Berkeley Madonna, MATLAB, and SimCYP.

  • Excellent interpersonal and communication skills coupled with strong influence and leadership skills.

  • Line leadership experience would be desirable

Location: Cambridge UK

Welcome to Cambridge, one of over 400 sites here at AstraZeneca, providing a collaborative environment where everyone feels comfortable and able to be themselves is at the core of AstraZeneca’s priorities, it’s important to us that you bring your full self to work every day. To help you maintain your best self, here’s a sneak peek into some of the things this site provides for you…

Where life meets Science…Chesterford Research Park offers advanced laboratory and office space set within 250 acres of idyllic parkland near Cambridge – modern, dynamic, flexible facilities perfectly appointed for biotechnology, pharmaceutical and R&D companies. You will have access to a stylish, fully air conditioned health and fitness centre, an onsite restaurant, Lunch & Learn development activities, all within a spacious environment while utilising the most advanced technology.

This role will then relocate to the Cambridge Biomedical Campus, when the site is completed - this site combines world-class biomedical research, patient care and education on a single site location in the heart of Cambridge.

Why AstraZeneca?

At AstraZeneca, we 're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We’re on an exciting journey to pioneer the future of healthcare.

So, what’s next?

  • If you are already imagining yourself joining our team, good, because we can’t wait to hear from you!

Competitive salary and benefits package on offer.

The successful candidate will have access to a flexible employee benefits fund, including holiday purchase and flexible time off, pension contributions, Share Save Plans, A performance recognition scheme and a competitive, generous remuneration package.

Date Posted


Closing Date


AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

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