AstraZeneca is a global, science-driven biopharmaceutical company dedicated to discovering, developing, and delivering innovative, meaningful medicines and healthcare solutions that enrich the lives of patients.
Location: Macclesfield, UK
AstraZeneca is a global, science-driven biopharmaceutical company dedicated to discovering, developing, and delivering innovative, meaningful medicines and healthcare solutions that enrich the lives of patients.
Pharmaceutical Sciences is a department within AstraZeneca R&D unit. The vision for Pharmaceutical Sciences is to deliver the therapies of the future through scientific leadership in drug delivery, design of synthetic routes and manufacturing of Active Pharmaceutical Ingredients (API) and drug product. Our portfolio of projects includes traditional small molecules, nucleotide-based therapies and nanomedicines across AstraZeneca's therapy areas.
An opportunity exists in Pharmaceutical Sciences for an exceptional individual in the area of solid-state chemistry/formulation, working across drug substance and drug product subject areas. We are looking for a hard-working and highly capable Senior Scientist to join our Early Product Development and Manufacturing (EPDM) team in either Macclesfield, UK.
You will work closely with analytical, formulation and biopharmaceutics scientists in EPDM as well as scientists in other functions to drive science and innovation within drug projects, including global collaboration with scientists at our Macclesfield, Cambridge, Boston & Gothenburg sites.
The successful applicant will become a core member of the global Solid-state skill area which is responsible for ensuring suitable physical form and formulation screening, selection and control within drug substance and product. The team supports the full discovery and early development stages up to Phase II clinical trials.
Accountabilities/Responsibilities
- Responsible for ensuring suitable physical form and early formulation screening, physical characterisation, form and formulation selection and control within drug substance and product.
- Represent solid state skill area in projects. Work closely with formulation, analytical, and biopharmaceutics scientists in EPDM as well as scientists in other functions to drive science and innovation.
- Deliver robust physical forms which meet the needs of the patient.
- Plan and conduct lab-based experimental work in accordance with project timelines.
- Keep abreast with the scientific literature and proactively apply existing and novel approaches to projects.
- Drive and lead science personally and within the department, manage external collaborations and publish novel work in peer reviewed journals.
Qualifications and Experience:
- Chemistry or Pharmacy PhD or be a graduate with relevant experience in the area of solid-state chemistry, formulation, physical chemistry or related subject areas.
- Screening and characterisation of solids (e.g. X-ray diffraction, spectroscopy, thermal analysis, microscopic techniques, moisture sorption etc.), a good awareness of analytical methodology and a passion for laboratory-based work.
- Experience/knowledge or a keen interest in the field of automation, simulation or prediction would be advantageous.
- Understanding of the principles and concepts of crystallisation.
- Amorphous materials and their characterisation will be helpful as would experience in examination of crystal structures and use of relevant software tools e.g. tools such as Mercury, Materials Studio etc.
- In depth understanding of how the physicochemical and solid-state properties of a drug, effect the manufacture, formulatability and in vitro and in vivo performance.
So, what's next?
This role is open from Friday 24th February 2023 and we welcome your application no later than 10th March 2023.
Applications must include your current CV, and a cover letter which presents your motivation and suitability for the role.
We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, sex, gender, gender expression, sexual orientation, age, marital status, veteran status, or disability status. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
