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Senior Scientist - Protein Scientist, Biologics Engineering, Oncology R&D

AstraZeneca UK

Location: Cambridgeshire

Job Type: Full time


At AstraZeneca, you’ll have the opportunity to make a meaningful difference in patients’ lives. With science at its heart, this is the place where breakthroughs born in the lab become transformative medicines – for the world’s most complex diseases. Answer unmet medical needs by pioneering the next wave of science, focusing on outcomes, and shaping the patient ecosystem. With our ground-breaking pipeline, the outlook is forward-thinking. Be proud to be part of a place that has achieved so much yet is still moving forward. There’s no better time to join our global, growing enterprise as we lead the way for healthcare and society.

AstraZeneca’s vision in Oncology is to push the boundaries of science to change the practice of medicine, transform the lives of patients living with cancer, and ultimately eliminate cancer as a cause of death. A broad pipeline of next-generation medicines is focused principally on four disease areas - breast, ovarian, lung and haematological cancers.

What you’ll do

We are looking for a highly motivated Senior Scientist to join our Biologics Engineering team in Cambridge, UK. As a Senior Scientist, you will be a key member of a team focused on developing the next generation of immune cell engagers. You will bring your knowledge and practical expertise in protein purification and antibody characterisation to develop the next generation of drug candidates.

  • Responsible for defining and executing experimental/platform strategies to deliver next-generation biologics, such as multi-specific mAbs, to support pipeline projects and technology delivery

  • Contributes to experimental strategy and implements and delivers recombinant protein expression platform development. Independently leads, plans, and prioritises work activities.

  • Maintains and applies extensive expertise in molecular biology (e.g. expression vector optimisation), protein engineering, protein expression (mammalian transient systems) and purification (e.g. automated liquid chromatography) to facilitate biotherapeutic drug discovery, makes detailed observations, analyses data, interprets results and devises solutions to sophisticated scientific problems

  • Establishes internal and external contacts and collaborations within the scientific field of value to the business and presents findings at internal (intra- and inter-departmental) project team and function meetings

  • Demonstrates strong interpersonal communication by establishing good working relationships with team and department members and others within the company

Essential Requirements

  • PhD with relevant experience or BSc/higher degree with equivalent lab-based experience

  • A deep level of knowledge and strong technical skills in molecular biology, biochemistry and cell biology. Experience with cell line generation is desirable.

  • Extensive experience in troubleshooting molecular biology and protein expression and purification

  • Experience in protein expression (bacterial and mammalian cells) and purification using AKTA systems

  • Protein characterisation by techniques such as analytical HP-SEC, Mass Spectrometry and thermostability studies

  • Extensive experience in antibody/protein characterisation, including in vitro biochemical assays (ELISA, WB, HTRF, SPR (Biacore) or BLI (Octet).

  • Good communication, capable of developing good working relationships with individuals across organisational boundaries and experience working within a team environment

Why AstraZeneca?

At AstraZeneca, we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference in medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.

So, what’s next?

Competitive salary & benefits

Close date: 20/03/2023

Where can I find out more?

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Date Posted


Closing Date


AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.