Senior Portfolio Manager (Commercial)

AstraZeneca UK

Location: Cheshire East, Gaithersburg, Maryland, Wilmington, Delaware

Job Type: Full time


Senior Portfolio Manager (Commercial)

Macclesfield (UK) Gaithersburg, Wilmington (USA)

Job Role

The Senior Portfolio Manager is responsible for managing the Commercial IT portfolio - currently estimated over $40M with over 70 in flight projects. The portfolio is delivered by the Commercial IT function supporting multiple AZ Commercial business units (BBU, OBU, International & Japan). This role will apply robust knowledge of portfolio management capabilities to improve practices, standards, reporting, and tools, and will demonstrate change management principles to drive the adoption of changes across the Commercial IT organization.

The successful candidate will connect multi-functional plans and resources to guide the Commercial IT organization and the broader business to enhance value and minimise risk in IT portfolio investments. They will build relationships with business and IT leaders to support strategic planning and project prioritisation to maintain focus on the organization’s strategic goals and objectives.

As part of the broader Strategy, Performance & Quality Portfolio Team, this role is expected to contribute to how we

  • Simplify to relentlessly create capacity,

  • Standardise by vigorously pursuing standard methodologies across IT

  • Evolve by pioneering new ways of working, and

  • Safeguard through the proactive maturation of IT processes and systems in order to enable #OneIT.

Technology at AstraZeneca is a home for purposeful disruptors!

Here our work has a direct impact on patients – transforming our ability to develop life-changing medicines. We empower the business to perform at its peak and lead a new way of working, combining innovative science with leading digital technology platforms and data. All with a passion to impact lives through data, analytics, AI, machine learning and more. In Business Partnering we will provide strategic partnership to the ITLT and the broader IT organisation. We will drive continuous improvement and alignment, as well as preparing the organisation to meet the needs of the future. As the Senior Business Partner you will report to the Director of Business Partnering in IT's Strategy & Performance function.

Key Accountabilities

  • Serve as a strategic partner for the Commercial IT group through in-depth analysis and insight into demand, portfolio and resource management capabilities.

  • Drive full transparency of the Commercial IT Portfolio, support prioritisation and investment decision making with the Commercial IT leadership team and business partners.

  • Manage the IT portfolio process including demand management/intake, prioritisation through project approval.

  • Create new value with their expertise in portfolio capabilities of demand management, resource management, portfolio management and financial thinking to support informed business decisions.

  • Implement changes to portfolio management related processes in their corresponding partner communities

  • Lead the development of solutions to problems identified through business performance data or partner feedback

  • Communicate performance and trends to ITLT to identify risks at the earliest stage possible

  • Oversee the ongoing portfolio financial reporting and advance where decisions/re prioritisation may need to occur by governance group(s).

  • Proactively advance and resolve critical issues.

  • Effectively communicate and build relationships across the organization. Advocating for business needs and ensuring timely response.

  • Measure portfolio health, status, financials and variances against a baseline

  • Manage routine quarterly and annual budget submission processes including communicating timelines, collecting and reviewing forecasts with and providing transparency to partners.

  • Work cross-functionally with:

  • Functional leadership as the key interface and source of management of business performance against key indicators, areas of risk, and actions to mitigate risks

  • Functional leadership and wider IT team to create and own a Performance Improvement plan and to drive the implementation of a performance management culture based on effective measurement & continuous improvement

Essential Experience

  • BA/BSc degree required, MBA or advanced degree preferred in Information Technology, Business Administration, or related field

  • Key experience managing significant project portfolio(s)

  • Understanding of Lean Portfolio Management concepts & processes

  • Progressive experience in IT business or financial management

  • Extensive experience leading multi-functional teams (direct line management or matrixed)

  • Solid skills using the suite of Microsoft Office products

  • Educated in Waterfall and Agile portfolio, program, and project methodologies as well as product/platform delivery models

  • Ability to frame and lead strategic portfolio investment discussions with IT and business partners

  • Ability to apply a strategic perspective to improve value delivery and implement decisions/changes tactically

  • Passionate about contributing to an organization focused on continuously improving processes and partner experiences.

  • Applies critical thinking to existing environment to identify and implement process improvement opportunities.

  • Ability to manage multiple tasks and deadlines with attention to detail, communicate effectively and deliver presentations to senior leaders.

  • Comfortable and skilled in operating in a complex operational matrix organization across diverse, global teams

  • Effectively collaborates, influences, and leads teams, leaders and executives through good interpersonal and communication skills

  • Ability to guide conflict and drive resolution

  • Apply change management principles to implement change across the organization.


At AstraZeneca, we 're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and spark your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. We foster an inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.


We’re a network of entrepreneurial self-starters who contribute to something far bigger. There’s a diversity of expertise in our Technology group that’s unique to AstraZeneca – it allows us to dive deep into exploring new leading-edge technology. We enable AstraZeneca to perform at its peak by delivering world-class technology and data solutions. Our work unlocks the potential of science. We optimise and evolutionise AstraZeneca by maximising efficiencies and finding new ways to drive productivity. From automation to data simplification.

We’re not afraid to take owner ship and run with it. Empowered with unrivalled freedom. A place to be open and transparent – we speak up, think creatively and share ideas. Our diverse contributions help us to make better decisions. But we have a constant drive to innovate, and an appreciation for high standards. It takes challenging the status quo to add value in our ever-evolving environment. We love it here because put simply, we make a meaningful impact.


Are you already imagining yourself joining our team? Good, because we’d love to hear from you! Click the link to apply and we’ll be in touch as soon as we can.


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Date Posted


Closing Date


AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.

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