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Senior Scientist, Antibody/ Protein Engineering, Biologics Engineering, Oncology R&D

AstraZeneca UK

Location: Cambridgeshire

Job Type: Full time


Join Francisca Wollerton at AstraZeneca a Senior Scientist within our Biologics Engineering (BE) team. You will provide critical antibody/protein engineering expertise to support the delivery of our next-generation biotherapeutics portfolio in the oncology therapeutic area, focusing on Immuno Oncology, multispecifics and Immune Cell Engagers.


AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies.


Granta Park Cambridge, UK is one of over 400 sites here at AstraZeneca, providing an environment where everyone feels comfortable and able to be themselves is at the core of AstraZeneca’s priorities, it’s important to us that you bring your full self to work every day. To help you maintain your best self, here’s a sneak peek into some of the things this site provides for you… Granta Park has a newly built gym with swimming pool, nursery and central food hub accessible to staff as part of the science park facilities. We also have our own bistro and deli in the AstraZeneca buildings. There are regular ‘Lunch & Learn’ events and after work socials with snacks and drinks on the last Friday of every month. This is our biggest and most spacious lab site in Cambridge…come and join us!


The Biologics Engineering team is responsible for the discovery and optimisation of biological candidate drugs across all AZ therapy areas such as oncology, respiratory and inflammation, cardiovascular, renal and metabolic diseases.

What you’ll do

  • Identify and develop innovative solutions to engineer the next generation of immune cell engagers and novel formats to support pipeline and technology delivery

  • Lead drug candidate/technology projects by planning, coordinating and prioritising engineering activities and working closely with colleagues from Oncology Biological Science in project teams.

  • Contribute to project/technology progression by independently designing and executing antibody isolation and characterisation experiments such as phage selection, high throughput cloning and expression, affinity and developability assays.

  • Maintain a well-developed understanding of approaches to biologics drug discovery and keep abreast of developments in immune therapeutics.

  • Provide technical training and supervise members of the team where required

  • Ensures own work and work of peers follows Good Laboratory Practice, Safety, Health, and Environment standards and all other relevant internal AstraZeneca standards and external regulations

Essential for the role

  • Ph. D. in a relevant field or equivalent experience

  • A deep level of knowledge and hands-on experience in antibody/protein engineering

  • Knowledge of the field of immunotherapy and its applications

  • Strong technical skills in molecular biology, cell culture, protein expression and purification, antibody and biophysical characterization

  • Ability to collaborate effectively, as demonstrated by publications

Desirable for the role

  • Previous experience of drug discovery project leadership

  • Previous experience of working on immune cell engagers

Why AstraZeneca?

At AstraZeneca, we 're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We’re on an exciting journey to pioneer the future of healthcare.

Close date: 22/03/2023

Competitive salary and benefits

So, what’s next?

  • Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you.

  • Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available, and we hope it’s yours.

  • If you’re curious to know more please get in touch with Louise Bennett.

Where can I find out more?

Our Social Media, Follow AstraZeneca on LinkedIn

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Date Posted


Closing Date


AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.