AstraZeneca are seeking an experienced medicinal chemist for the Tumour Targeted Delivery Chemistry group. Based at the TTD Chemistry site in London, you will be an integral part of the medicinal chemistry teams working on the design and synthesis of linker payload molecules for novel antibody drug conjugates (ADCs).
ADCs are among the fastest growing drug classes in oncology. This position offers the successful applicant the opportunity to have an impact on the rational design of the linker payloads and conjugation technology for the next generation of ADCs.
About AstraZeneca
AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of most serious diseases. But we're more than one of the world's leading pharmaceutical companies. Here you'll have the chance to define a difference to patients' lives. With science at its heart, this is the place where breakthroughs born in the lab become transformative medicines - for complex diseases. Answer unmet medical needs by pioneering the next wave of science, focusing on outcomes and crafting the patient ecosystem. With our pipeline, the outlook is forward-thinking. Be proud to be an employee of a place that has achieved so much, yet is still moving forward. It's time to join our global, growing enterprise as we own the way for healthcare and society.
Site description
Welcome to our Spirogen site, part of the AstraZeneca Group - Whitechapel, London… one of over 400 sites here at AstraZeneca, providing an environment where everyone feels comfortable and able to be themselves is at the core of AstraZeneca's priorities, it's significant to us that you bring your full self to work every day. To help you maintain your best self, here's a sneak peek into some of the things this site provides for you After-work events, Lunch & Learns, spacious office working environment, Networking events. Situated in the heart of London's historical east end close to the fashionable areas of Shoreditch, Spitalfields and Brick Lane with excellent public transport links to central London.
Business area
Join us in fulfilling our ambition to be world leaders in Oncology. We are already the fastest growing team within AstraZeneca and across the industry, and there are countless new indications and targets in our game-changing pipeline. We deliver this value through launch excellence, commercial efficiency and improving the lifecycle. By using our commercialised portfolio we are confident we can change the practice of medicine and redefine cancer treatment.
What you'll do
Lead a team working on the rational design of linker payloads and conjugation technology for the next generation of ADCs. Provides medicinal chemistry knowhow and technical input to expand the role of ADCs beyond classical cytotoxic payloads
Devise and execute on medicinal chemistry strategies that will enable the discovery of novel, differentiated small molecule candidates for tumour targeted delivery by incorporating sound structural, pharmacological, physicochemical, metabolic, and safety considerations
Cultivate interdisciplinary collaboration and build positive relationships with partner lines
Applies technical knowledge and expertise to achieve project targets in a timely fashion and to agreed quality standards.
Stays on top of trends within the external scientific world to transform novel ideas appropriately into research programs and activities within AstraZeneca
Plays a role in enhancing the external reputation of AstraZeneca's medicinal chemistry and synthetic capabilities through publications and presentations at conferences.
Ensures own work, and the work of others, is performed in accordance with appropriate Safety, Health & Environment (SHE), quality and compliance standards, e.g. Good Laboratory Practice (GLP)
Essential for the role
Doctoral degree (PhD) or equivalent in synthetic organic chemistry or medicinal chemistry
Experience in the biotech and/or pharmaceutical industry, with a strong background of scientific innovation and success in delivering clinical candidates
Experience of small molecule drug design techniques, including structure-based design, property and ligand-based design, pharmacokinetics, and hit ID strategies
Experience in leading a chemistry project
Theoretical knowledge and long term experience of relevant techniques and technologies
Understanding the process of successful drug discovery/drug development
Understanding of patent and IP strategies
Desirable for the role
Line management experience
Previous experience in the field of ADCs
So, what's next?
Are you already thinking of joining AstraZeneca? Good, because we can't wait to hear from you. Are you ready to bring new insights and fresh thinking to the table? Brilliant! We have one seat available, and we hope it's yours.
If you're curious to know more please apply today!
Competitive salary package and benefits
Close Date: 28/04/2023
Where can I find out more?
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