Associate Principal Scientist, Early Development - Respiratory

AstraZeneca UK

Location: Cambridgeshire

Job Type: Full time


Be empowered to be innovative and creative where difference is valued

Join a place built on innovation and creativity. Where different views and perspectives are welcomed and valued. An environment that champions inclusion, and teams that reflect the diversity of the communities that we serve.

Who we are

A hard-working team, we are united and motivated by our shared purpose – to deliver life-changing medicines. We come to work each day to make a difference – to patients, society and our company.

What we do

We are a global, science-led BioPharmaceutical business and our innovative medicines are used by millions of patients worldwide.

How we do it

Committed to living our values – they guide our behaviours, actions and decisions, everyday.

Are you a passionate Scientist striving to make a true impact on patients’ lives? The vision of AstraZeneca Early Respiratory & Immunology is centred on delivering life-changing therapies that advance world health and help fight and cure disease. Here, you’ll have the opportunity to make a difference in people’s lives every day. Are you ready to join us and see what science can do?

At AstraZeneca, we believe in the potential of our people and you’ll develop beyond what you thought possible. We make the most of your skills and passion by actively supporting you to see what you can achieve no matter where you start with us.

We are seeking a highly motivated Associate Principal Scientist researcher to join the Bioscience Asthma & Skin Immunity research group in Cambridge, UK to lead independent research projects focused on identifying and validating new drug targets for patients with lung pathogenesis. Within our Cambridge based research team, we are seeking an experienced research scientist with a strong understanding of lung biology and experience with primary model systems. In this role, you would be expected to demonstrate an exceptionally high level of enthusiasm for innovative scientific research leading to the discovery and development of novel therapeutics. Ideally, you have some expertise in in Lung immunology, modelling lung disease using primary cell cultures and co-cultures, and an ability to apply this experience to an understanding of the basic mechanisms of human lung pathologies.

What you’ll do:

This job is a scientific leadership role, and you will have significant opportunity to drive the direction of drug projects. The candidate will ensure delivery of preclinical and translational data in support of key portfolio program milestones, drive identification of novel targets partnering with multiple functional teams and external collaborators, drive technical excellence in bioscience research. A background in human lung diseases and translational approaches to understand basic biological mechanisms in disease is needed.

The role will be based in Cambridge within AstraZeneca’s state-of-the-art laboratories where you will follow the science to help drive innovation and advance medicine to help improve patient lives

Key Responsibilities and Accountabilities:

  • You will drive new target identification strategies and oversee the design and execution of bioscience in vitro and in vivo experiments integrating both disease and pathway approaches in support of portfolio programs

  • You will present specific target ideas to target review meetings, leadership team and Research Board

  • Work closely with key leaders in partner functions to ensure project goals are met

  • Work collaboratively with other teams within and outside of Early Respiratory and Immunology in Cambridge and with our sites in Gaithersburg, US and Gothenburg, Sweden.

  • Drive innovation and scientific excellence through internal scientific development, publications in high impact journals and presenting data at conferences.

  • Will actively search, establish, and manage external collaborations with disease experts

  • Create and maintain a work environment in which scientific challenge and innovation are maximized

  • Mentor scientists in Bioscience, Asthma and Skin Immunity team

  • Encouragement and support will be provided to help you develop specialist knowledge and skills.

Required Education, Skills and Qualifications:

  • A Ph.D. in Immunology, Biochemistry or a closely related field followed by a minimum of 5 years relevant laboratory experience with expertise in lung biology

  • Track record of scientific creativity and ability to drive own research ideas to a successful conclusion, demonstrated by successful grant proposals as well as strong publication record.

  • Extensive scientific network and demonstrated ability to establish and lead successful collaborations with internal and academic experts

  • Outstanding team working skills and a consistent record of working collaboratively to ensure scientific excellence and rapid progression of projects

  • Experience with mentoring students at the undergraduate and Ph.D. level.

  • Strong leadership capabilities with emphasis of people management and development of others

  • Drive for constant personal development and increasing skill base.

Desired Skills:

  • Experience with smooth muscle cell and epigenetic biology is an advantage.

At AstraZeneca, we 're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, sex, gender, gender expression, sexual orientation, age, marital status, veteran status, or disability status. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

So, what’s next?

Are you already imagining yourself joining us? Good, because we can’t wait to hear from you!

Date Posted


Closing Date


AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

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