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Senior Scientist - Biopharmaceutics

Cheshire East
Full time
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AstraZeneca UK
Healthcare & medical
10,001+ employees
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Senior Scientist - Biopharmaceutics

Follow the science to explore and innovate

At AstraZeneca, we unlock the power of what science can do. Empowered to explore, everyday we work towards our ultimate aim – treating, preventing, modifying and even curing complex diseases. With an unwavering belief in following the science we unleash our curiosity, investing in key areas, harnessing innovative technologies and taking smart risks. Help to shape the future of healthcare as we take our pipeline from strength to strength!

Business area

To meet patients’ needs, AstraZeneca recognises the opportunity to apply a diverse range of new modality technologies to design novel therapeutics. This is exemplified by the increased number of new modalities entering clinical development.The New Modalities and Parenteral Development department (NMPD) has accountability for developing the pipeline of both new modality projects and traditional synthetic molecules requiring parenteral delivery.

It sits within the Pharmaceutical Technology and Development (PT&D) function. PT&D are the bridge which turns brilliant science into effective medicines that help millions of people. We work across the entire value chain, designing and delivering the active ingredients, formulations and devices required to support new and existing medicinesthat help millions of people.

The role

An exciting opportunity has arisen for a specialist in Biopharmaceutics to join our Pharmaceutics capability in NMPD, Macclesfield, UK, at the Senior Scientist level.

In NMPD, you will be a key member of a group responsible for generatingdeep Biopharmaceuticsunderstanding of drug products including conventional dosage forms, enabling formulations, nanomedicines and advanced drug delivery technologies across multiple delivery routes.We will rely on you to provideBiopharmaceuticsknowledge, andapply the latest in-vitro or digitalapproaches,in orderto build mechanistic understanding of drug product performance and design bridging strategies.The resulting insights will be used to support drug projects from the early clinical phase through to commercial filings.

You will work collaboratively across boundaries to achieve these goals with team members from multiple skill areas (e.g. analytical, material science, engineering, formulation, packaging, devices, clinical, supply chain and many more). 

Typical responsibilities for the successful applicant will include: 

  • Ensuring development of robust products and manufacturing processes through support of their bridging and control strategies, marketing applications and downstream commercialisation activities. 

  • Building, documenting and clearly communicating Biopharmaceutics knowledge for assigned drug products.

  • Working effectively with colleagues across Product Development, Pharmaceutical Sciences and Operations to ensure the successful delivery of drug projects spanning all phases of development. 

  • Authoring of regulatory documentation to support clinical trial and marketing applications and ensure continued and safe access of our products to patients. 

  • Collaborating within the skill area to develop Biopharmaceutics technology strategies and deliver capability build activities.

  • Providing technical supervision and mentoring to peers and students. 

  • Driving innovation, securing intellectual property and enhancing AstraZeneca’s scientific reputation by publishing high calibre research and engaging in external collaborations. 

Required Skills & Knowledge

  • Degreein a relevant subject leading toindustrial or academic experience of applying Biopharmaceutics knowledge to Pharmaceutical problems.

  • Good understanding of the relationship between in-vitro drug product properties and in-vivo pharmacokinetic performance, ideally with knowledge of the link to control strategy development

  • Experience of using Physiologically based Biopharmaceutics modelling (PBBM) and/or novel in-vitro techniques to support formulation development. 

  • Strong collaborative working and communication skills, including the ability to work effectively with colleagues from diverse backgrounds and skill areas. 

  • Excellent organisational and planning skills with a track record of delivering to the agreed time and quality. 

Depending on the ability and experience of the successful applicant, coaching and training will be provided to ensure optimal delivery against the role.

Be empowered to be innovative and creative where difference is valued

In NMPD and AstraZeneca, we 're dedicated to being a Great Place to Work, where you are empowered to push the boundaries of science and fuel your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. We have an inclusive culture that fosters diversity and collaboration and are committed to lifelong learning, growth and development. We also understand the importance of managing the demands of both home and work life. To support this, many of our staff work flexibly in different ways, including working part-time, flexible start/finish times etc. We will consider requests for flexible working for this role and encourage applicants to talk to us at interview about the flexibility you need. 

So, what’s next…

Are you ready to bring new ideas and fresh thinking to the table? Excellent! We have one seat available and we hope it’s yours!Please note applications must be made before the closing date below and include your current CV and a cover letter.

Date Posted


Closing Date


AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.