Senior Process Engineer - Drug Substance Manufacture (DSM)

Senior Process Engineer

Macclesfield

Make a meaningful impact on people’s lives with life-changing medicines.

We are driven by our commitment to deliver accelerated growth for AstraZeneca and to make people’s lives better. It pushes us to keep building on our foundations and progressing as we turn our ever-growing and increasingly complex pipeline from molecule to medicine. Be part of evolving how we work with Lean, cutting-edge science, digitalisation and sustainable practices.

Pharmaceutical Technology and Development (PT&D) is the bridge that turns forward-thinking science into actual medicines that help millions of people. We work across the entire value chain, designing and delivering active ingredients, formulations and devices required to support new medicines – from supplies for use in early toxicology studies and clinical trials to developing the technology to ensure drugs can be scaled up for commercial manufacture.

Drug Substance Manufacture (DSM) is responsible for the internal manufacture of Drug Substance / API (Active Pharmaceutical Ingredient) for formulation development, pre-clinical and clinical development studies. Our manufacturing assets include 5 Pilot Plant facilities and a Particle Size Reduction (PSR) facility.

We also support the rapid development of commercial processes by flexible accommodation processes and experimentation at scale. DSM is part of the Clinical Manufacturing and Supply (CM&S) function within PT&D, Operations.

What you'll do:

This opportunity is a Senior Process Engineer working within our Projects, Process and Technology Team. Collaborating within a team of technical managers and process engineers you'll deliver the API, process data and scale-up learning to support the AZ development programme. You will be accountable for delivery of technical work packages and engineering projects within the DSM pilot plants.

You will be responsible for delivery of the process engineering activities required to support accommodation of new manufacturing processes and technology within the Pilot Plant. You will also be required to support product manufacture by providing technical understanding to facilitate problem-solving, and may act as an engineering specialist on larger capital project teams.

You'll be a change owner within the facilities, accountable for crafting and managing temporary and permanent plant changes, to support specific product accommodations, along with installation of new technology and improvements to build the pilot plant capability.

We'll expect you to adhere to internal and external regulations, including safety, health, environmental and GMP (Good Manufacturing Practice) standards, fiscal and business procedures. We will also encourage you to manage, improve and own elements of our key business processes, to ensure that we maintain our licence to operate, and demonstrate excellence in SHE and GMP.

We'll need you to be able to work independently, and to lead interactions within multi-functional teams. These will include DSM operational and maintenance teams, site project teams, external contractors and AZ support functions including SHE and QA teams.

You will also need to develop networks, in particular building, and maintaining excellent working relationships with the Process Engineering teams within Chemical Development. While sharing scale-up learning and successes across the wider business. You will provide engineering mentorship to junior team members and apprentices.

Essential criteria:

• You will hold a relevant chemical engineering degree (preferred) or recognised chemical engineering training route (e.g. apprenticeship with HNC/HND or equivalent)
• A confident and engaging communicator who can influence a variety of business partners to drive success
• Comfortable working in a dynamic environment and managing risk
• Significant experience of chemical manufacture, preferably within the pharmaceutical sector

Desirable criteria:

• Chartered or working towards Chartership with an appropriate engineering institution
• Experience of Lean manufacturing and problem-solving
• Experience of handling plant changes in a regulated environment

So, what’s next

If you are interested in this outstanding opportunity to pioneer a new future to meet global healthcare challenges, apply today!

Global Career Level

D

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

Date Posted

22-May-2023

Closing Date

08-Jun-2023

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.