Scientist/Senior Scientist, Neuroscience (fixed-term 12 months)

Cambridge UK

Competitive salary and benefits

Bold Disruptors. Push the boundaries of science. Fearlessly break new ground.

Work at the cutting-edge, where scientific innovations and an ambitious spirit are the norm.

And in return… we’re looking for curious minds, comfortable taking sensible risks and learning from failures.

Cambridge is a truly international and inclusive environment. We encourage the contribution of people from all backgrounds, beliefs and walks of life.

This is the place to go beyond discovery – we think holistically about patients and are always learning from those living with diseases. We harness digital, data science & AI to fast-forward our research. Making sure work born in a lab can make a real difference.

What you’ll do

We are looking for a laboratory-based scientist working within the Neuroscience Discovery group. You will have responsibility for delivering a range of drug discovery and development assays and activities, both cell-based and behavioural, to support the preclinical project portfolio across the areas of neurodegeneration and pain. You will also contribute towards the identification and validation of novel drug targets.

Qualifications

• PhD in Neuroscience or related fields or master’s degree with extensive laboratory experience and knowledge of the drug discovery process
• A well-developed understanding and working application of mechanisms of pain or neurodegeneration with relevant cellular biology and in vivo pharmacology expertise
• Able to plan, design and implement a wide range of cell-based and/or behavioural experiments
• Experience in culturing and utilizing cell lines
• Hands-on experience in cell biology, molecular biology, and biochemistry techniques

Preferred qualifications

• Experience with a wide range of cellular and biochemical assays such as reporter assays, immunofluorescence, western blotting, HTRF, AlphaLISA, Mesoscale, ELISAs, or qPCR
• Experience in culturing human iPSC-derived neuronal/glial cells, and/or primary rodent neuronal/glial cells
• Experience in gene delivery (transient transfection, viral transduction) and/or knockdown/CRISPR-knockout
• Experience in running in vivo behavioural assessments and/or inflammatory and neuropathic pain assays
• Previous experience in preclinical drug discovery (academia or pharma) or working in a laboratory-based CRO role would be ideal
• Understanding of the pharmacological analysis, affinity, and drug potency to aid compound selection
• Good organizational skills with ability to manage multiple priorities
• Able to work both on a team and independently within a matrix project team
• Experience in making networks - establishing internal collaborations, and in identifying and setting up external collaborations
• Experience in the design and execution of in vitro and/or in vivo/ex vivo studies with external vendors/CROs to support a project

Why AstraZeneca

At AstraZeneca, we 're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.

So, what’s next?

Complete your application before the below closing date!

This role is open from 5th July 2023 until 21st July 2023.

Where can I find out more

LinkedIn https://www.linkedin.com/company/1603/

Facebook https://www.facebook.com/astrazenecacareers/

Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

Date Posted

Closing Date

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.