Senior Research Software Engineer, Genedata Biologics – Biologics Engineering, Oncology R&D
Job Type: Full time
The Biologics Engineering team is responsible for the discovery and optimization of next generation biological drug candidates for all key therapy areas across AstraZeneca, and for developing in-house biologics discovery platforms and novel drug modalities to address unmet medical needs.
Central to this effort operating at a Senior Scientist level is the development of end-to-end data management and analysis capabilities to deliver novel biologics drugs. You will become part of an interdisciplinary Bioinformatics team, working at the centre of research and development to create an active learning system for biologics engineering, in which model predictions guide lab experiments, lab automation generates high-throughput data for model training, and predictive models are updated as new data are generated.
As part of this effort, you will work closely with experts in data management, software engineering, lab automation, computational modeling and machine learning, with access to biologics R&D data across AstraZeneca and the potential to generate new data to inform predictive models.
AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies.
Granta Park Cambridge, UK, is one of over 400 sites here at AstraZeneca, providing an environment where everyone feels comfortable and able to be themselves is at the core of AstraZeneca’s priorities, it’s important to us that you bring your full self to work every day. To help you maintain your best self, here’s a sneak peek into some of the things this site provides for you… Granta Park has a newly built gym with swimming pool, nursery and central food hub accessible to staff as part of the science park facilities. We also have our own bistro and deli in the AstraZeneca buildings. There are regular ‘Lunch & Learn’ events and after work socials with snacks and drinks on the last Friday of every month. This is our biggest and most spacious lab site in Cambridge…come and join us!
In the Oncology Business Unit we relentlessly follow the science to deliver more effective treatments to patients in need. Our dedication means we purposefully push back the limits of knowledge to change the practice of medicine. To ensure no patient is left behind, no matter what stage of disease. Fast-paced, it takes agility and responsiveness to stay committed in our pursuit of excellence.
What you'll do
This role provides the opportunity for a motivated research software engineer to develop end-to-end data management capabilities that will significantly impact the delivery of the novel biologics drugs of the future.
Work with scientists across Biologics Engineering to develop end-to-end data management capabilities for biologics discovery.
Develop SQL code to configure and customize commercial Genedata Biologics software for tracking biologics discovery data from antibody screening, protein engineering and protein production.
Extend the functionality of Genedata Biologics by developing custom computational tools using its Java Software Development Kit, for data ingestion from lab instruments and for data analysis.
Collaborate with IT functions responsible for the deployment and maintenance of the live Genedata Biologics system and its integration with external databases.
Collaborate with web application developers to integrate the Genedata Biologics system with custom applications for experiment design and data analysis.
Collaborate with machine learning colleagues to develop an active learning system that continually trains machine learning models on data from biologics experiments and uses these data to inform subsequent experiments. Learn about leading machine learning methods for biologics design and for active learning applied to biologics experiments.
Essential for the Role
A master's degree or equivalent experience in computer science or in a relevant computational field & at least one year of exp
Experience with SQL, including configuring and querying databases programmatically.
Experience developing high-quality software in Java or a related language.
Experience with software development best practices.
Experience working with Genedata Biologics or similar platform for biological data management.
Experience working within a team environment.
Acts with integrity and does the right thing.
Desirable for the Role
A PhD or equivalent research experience at the intersection of computational and biological sciences.
Knowledge of data formats for lab automation equipment.
Experience developing data analysis methods and an understanding of the data requirements for downstream machine learning.
At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big.
Competitive salary & benefits
Close date: 21/09/2023
Where can I find out more?
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AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.