R-174194: Cell Engineering Scientist - Lead the way into scientific breakthroughs

Cambridge, UK

Competitive salary & benefits

Are you an experienced Cell Engineer looking for your next opportunity?

Be part of the team where you are empowered to follow the science

This is the place for curious minds. Dig deep into the biology of complex disease and uncover breakthroughs!

How far can you go at AstraZeneca UK? In the corridors and cafeterias of Cambridge, you will pass Nobel prize winners and esteemed pioneers of AstraZeneca’s leading medicines. Follow in their footsteps.

We are seeking a passionate Senior Scientist to embed themselves into our Cell Engineering team. This is an outstanding opportunity to join a fast-growing team within a vibrant environment focused on modelling complex diseases in vitro using the most advanced genome engineering methods.

What you'll do

You’ll focus on applying genome engineering methods to characterise the functional consequences of genetic variants and variants of uncertain significance at scale, with the aim of advancing our understanding of complex human disease.

This is a laboratory-based role, where you will design and lead experiments to progress our drug discovery pipeline. As part of our innovative team, you will also be supported and encouraged to contribute to the improvement of current genome engineering technologies. You will be comfortable working as part of a cross functional team to interpret data and determine next steps to drive projects forwards. You’ll interact with colleagues across our global organization and with high profile external collaborators. You’ll have the opportunity to maintain scientific excellence, presenting data to key collaborators and colleagues internally and at external conferences, and publishing in peer-reviewed journals. Working within AstraZeneca’s Discovery Sciences unit, you’ll be joining a community of scientists with broad technological expertise dedicated to drug discovery.

As an outstanding Senior Scientist with relevant knowledge in molecular biology, genetics and genome engineering, your passion for science and desire to positively impact the lives of patients will shine through. At AstraZeneca we work together to provide medicines that make a real difference in patient care. Our ambitious and collaborative culture ensures you'll feel valued and rewarded for your ideas and contributions.

Essential Criteria

• PhD in cell biology, molecular biology, cell biology, genetics or equivalent level of experience within academia or industry
• Significant expertise in molecular biology for genome engineering applications, including vector design, cloning and propagation
• Expertise in CRISPR-based insertion of large genetic cargo
• Competent in the practical application and delivery of genome engineering techniques including CRISPR, viral delivery (including lentivirus and AAV) and transposons
• Strong experimental design and problem-solving skills
• Scientific excellence as shown by previous work, publication history and references from scientific mentors
• Excellent team working, communication and networking skills with experience of interacting effectively across interfaces of specialisms, culture and expertise

Desirable Criteria

• Experience in diverse variant library design, cloning and propagation
• Experience in Next Generation Sequencing
• Creating and/or working with complex cell models of human disease

*** We will be reviewing applications on a rolling basis and reserve the right to close the advert at short notice, should we identify a suitable candidate ahead of the scheduled closing date. ***

AZ Cambridge

An exciting bioscience hotspot, Cambridge is home to one of AstraZeneca’s three strategic, global R&D Centres, alongside Gothenburg and Gaithersburg. Over 3,600 employees work from our various sites across Cambridge and our offices are internationally renowned for attracting exceptional talent.

Currently based at our Aaron Klug building on Granta Park, the Cell Engineering team are excited for their pending relocation to our brand new, innovative R&D facility, which was officially un-veiled by His Royal Highness, The Prince of Wales in November 2021.

The Discovery Centre (DISC), located at the heart of the Cambridge Biomedical Campus, is designed to play a central role in our mission to deliver life-changing medicines to patients. As our largest research and development centre in the UK, it will have more than 2,000 people working across therapy areas and drug discovery and development once fully occupied.

Find out more about our Cambridge campus and the DISC, here: https://www.astrazeneca.com/our-company/our-locations/cambridge.html

Why AstraZeneca?

At AstraZeneca, when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being driven - finding those moments and recognising their potential. This means we’re opening new ways to work, ground-breaking methods and bringing unexpected teams together. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be!

So, what’s next?
This role is open from Thursday, 13th July 2023, and we encourage you to apply as soon as possible, but ahead of the scheduled closing date of Sunday, 30th July 2023.

Where can I find out more?
Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

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Date Posted

Closing Date

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.