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Senior Scientist (in vitro Assays/ ADCs), Bioscience, Early Oncology R&D

AstraZeneca UK

Location: Greater London

Job Type: Full time


As a Senior Scientist within Bioscience, you'll have a good understanding of the range of procedures relating to bioanalysis/bioscience. You will expertly design and conduct laboratory projects/experiments, develop methods, generate interpret and report scientific data. You'll also be proficient in trouble shooting and theory.

Site description

Our site in Whitechapel (London, UK) plays host to a talented, motivated, and diverse interdisciplinary team that forms part of AstraZeneca’s Tumour Targeted Delivery (TTD) group. We believe strongly in creating an environment where you feel comfortable being yourself and allowing you to flourish in your role here. Outside of your core duties we offer regular after-work events and opportunities to socialise with your colleagues. With great transport links (Elizabeth Line, Overground, Underground), Whitechapel offers an attractive location that is accessible to commuters as well as locals. Moreover, the neighbourhood is home to great restaurants, bars, and shops and is just a short walk away from other great areas such as Shoreditch, Spitalfields and Brick Lane.

Business area

In the Oncology Business Unit we relentlessly follow the science, challenging the norm to deliver more effective treatments to patients in need. Our dedication means we purposefully push back the limits of knowledge to change the practice of medicine. To ensure no patient is left behind, no matter what stage of disease.

What you'll do

  • Designs, plans and performs high-quality in-vitro drug discovery experiments independentlyin the oncology disease area to assess efficacy, triage and understand mechanism of action of lead candidates

  • Delivers & analyses data, providing interpretations using scientific rigour from own data and that of others, andcommunicates results to team members in a clear and concise manner with a clear understanding of its implications within drug discovery

  • Shows scientific leadership to identify and develop new complex cell basedbioassay ideas, implement new models/assays/latest technology relevant to bioconjugatesand their small molecule payloads

  • Works collaboratively with team members and cross-functionally to support early drug discovery platforms and projects and establish opportunities to succeed

  • Maintains a well-developed understanding of approaches to bioassaysand antibody-drug conjugates, applying a broader functional knowledge to support the team

  • Actively develops own skillsetand alsoenablescolleagues to thrive through mentoring, regularly sharingexpertise and relevant scientific papers and as a role modelfor Good Laboratory Practice and Safety, Health and Environment standards

Essential for the role

  • Ph.D. in Biochemistry, Cell Biology, Bio/chemical engineering or relevant discipline

  • B.Sc./M.Sc. in above disciplines with relevant industrial experience

  • Deep understanding of protein biochemistry and cell biology

  • Extensive hands-on experience in cell culturewith a track-record of establishing, validating and conducting in vitrobioassays and application to drug discovery

  • Experience with GraphPad Prism, microplate readers and liquid handling automation

  • 3D complex cell culture, target engagement (e.g.WB), and cell imaging experience would be highly desirable

  • Protein/bioconjugate characterisation (e.g.HPLC/LCMS)experiencemight be beneficial

Desirable for the role

  • Protein/bioconjugate characterisation (e.g.HPLC/LCMS)experiencemight be beneficial

So, what’s next?

  • Are you already envisioning yourself joining the team? Good, because we can’t wait to hear from you.

Competitive salary package and benefits

Close Date: 22/09/2023

Where can I find out more?

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Date Posted


Closing Date


AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.