Do you have expertise in, and passion for science? Are you ready to work at the cutting-edge, where scientific innovations and an entrepreneurial spirit are the norm? We’re looking for dynamic thought leaders with curious minds, who are comfortable taking smart risks and constantly challenging the boundaries of science all the while learning and developing core skills and experiences.

What we do

We are a global, science-led Biopharmaceutical business and our innovative medicines are used by millions of patients worldwide.

Why we love it

The future is bright at AstraZeneca as we bring ground-breaking therapies to complex disease to patients with critical needs. Scientific innovations are at the core of what we do across our industry leading portfolio which drive exciting opportunities and varied work. We’re on an exciting journey to pioneer the future of healthcare!

The role

As part of the Integrated Bioanalysis (iBA) Global Team, you will report directly to the head of integrated Bioanalysis, responsible for leading all aspects of bioanalysis supporting discovery efforts. You will use your comprehensive understanding of bioanalysis in early drug discovery across multiple modalities and theraputic areas. Responsible will include but limited to driving discovery bioanalytical strategy while focussing on scientiifc and technical innovation to drive portfolio value. You will mange and develop high caliber sceintific staff across multiple sites focussed developing early bioanalytical strategy to deliver complex technical solutions. The successful candidate will be a recognized thought leader in the field of discovery bioanalysis supporting early portfolio needs. An enterprise leader, you will be capable of managing a complex portfolio requiring state of the art scientific and technical solutions. The ideal candidate will collaborate across a range of stakeholders and act as senior scientific leaders. You will be responsible for ensuring delivery across all aspects of discovery needs ensuring operation effectiveness through innovated ways of working. This important leadership role is responsible for strengthening technical capabilities and talent development to design and implement robust bioanalytical strategies including but not limited to endpoints such as PK/ CK, immune response and biomarkers when required to support the AstraZeneca pipeline. The ideal candidate will have a strong track record in drug discovery environment with a particular focus on novel modalities such as CAR-T, AAVs, LNPs, ADCs and alternative antibody formats as well as MAbs. Working with a dynamic team in a matrixed environment you will need to interact with stakeholders, manage expectations, input to project strategy and delivery within a highly skilled bioanalytical team. You will have the opportunity to have an immediate and lasting impact to our diverse pipeline.

The Integrated Bioanalytical team within Clinical Pharmacology and Safety Sciences provides broad discovery, preclinical, and clinical support including life cycle management across all therapeutic areas enabling pipeline delivery, decision making, innovation and advancement to improve the lives of patients through life-changing medicines.

What you’ll do

• You will be located at our Gaithersburg US or Cambridge UK site where you will work alongside TA leads and stakeholders.

• In this a critical, highly visible role you will work across all therapeutic areas and early research.

• As a scientific thought leader, you will be required to make a profound impact to strategic and scientific direction of the portfolio.

• You will utilize your experience and proven track record to drive novel technology development and make critical investment decision in new technologies.

• You will also work with a range of colleagues across a number of key groups influencing drug design, exposure efficacy relationships and safety and tolerability preparing for candidate selection.

• As global leader, you will be responsible for enhance the reputation of Integrated Bioanalysis for scientific excellence by presenting at internal and external meetings, and publishing manuscripts.

The successful candidate will work closely with AstraZeneca laboratory groups within Integrated Bioanalysis and our vendor partners to ensure appropriate bioanalytical and platform strategies, scientific oversight, and delivery across all aspect of the portfolio fostering an environment of scientific knowledge exchange and collaborative contribution.

Education/Experience required:

• PhD or MSc. in Analytical Chemistry, Biochemistry, molecular biology, Immunology, or related life science disciplines with significant relevant industry experience

Essential for the role:

• Capable of working in a dynamic high-pressured environment, willing to take calculated risks while continually adjusting your approach to meet to drive portfolio value.

• Proven track record as a leader in discovery bioanalysis or related disciplines

• Ability to drive complex scientific strategies and influence novel target development.

• Worked collaboratively with stakeholders, providing solutions to challenges, and mitigating risk.

• Proven track record developing and implementing complex novel solution that have a profound impact portfolio value.

• Able to evaluate and provide strong business case for new technology investment.

• Expertise in variety of technical applications that advance scientific value, ideally in target biology and mechanistic and safety understanding through impact to biomarkers.

• Advance technical applications through novel assays to provide critical PK/PD understanding in early research.

• Interpretation of integrated and complicated datasets that aid in advancing portfolio.

• Ability to handle multiple projects and / or tasks concurrently in a fast-paced environment.

• Ability to evaluate and mitigate portfolio risk via generation of critical data.

• Ability to develop, coach and mentor.

• Background in pharmaceutical research

• Proven publication and presentation record

• Exceptional verbal and written communication skills

• Ability to develop, coach and mentor.

• Proven track record influencing the bioanalytical community including an extensive publication and presentation record.

• Exceptional verbal and written communication skills

Desirable for the role:

• Experience in a broad range of novel therapeutic modalities such as cell therapy including CAR-T, gene therapy delivery including AAVs and LNPs as well as RNA therapies, ADCs, immune therapeutics, and conventional small molecules.

• Experienced in multiple therapeutic modalities with specific experience in ADCs, novel antibody format and Cell and Gene Therapy

• Awareness of regulatory submission needs across geographies.

• Proven acumen to drive business value decisions.

So, what’s next?

Are you already imagining yourself joining us? Good, because we can’t wait to hear from you!

Advertising opens on October 10, 2023 and we welcome with your application; CV and cover letter, no later than November 10, 2023.

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working give us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn’t mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

Date Posted

Closing Date

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics (e.g. race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status). We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.