Senior Analytical Scientist – Tides (Synthetic Peptides or Oligonucleotides) API, Macclesfield (UK)

Open date: 12/10/2023

Close date: 26/10/2023

Are you a strong analytical Scientist with Tides (synthetic peptides or oligonucleotides) analysis experience looking to join an innovative and vibrant team that uses cutting-edge development of new modalities to meet patient needs? If so, we’ve had an exciting opportunity released working within our Pharmaceutical Technology and Development (PT&D) department.

In our fast-paced, growing environment, embrace an exciting opportunity to build a long-term, varied career. With a huge variety of global opportunities and learning from other teams this is the place to embrace lifelong learning and build capabilities, setting your own direction and pace.

PT&D is the bridge, which turns brilliant science into medicines that help millions of people. Working across the entire value chain, designing and delivering active ingredients, formulations and devices required to support new medicines – from supplies for use in early toxicology studies and clinical trials to developing the technology to ensure drugs can be scaled up for commercial manufacture.

Key responsibilities:

As a Tide analytical chemist working closely with process chemists, engineers, project managers and other scientists, you will contribute to pharmaceutical development programmes for Tide APIs, supporting project progression through late clinical development and launch. You may lead significant parts of analytical chemistry development programmes, directing the work of other scientists. Your role will involve:

• Leading Tide APIs analytical activities to support project progression from clinical development phases through to late development and commercialisation.
• Collaborating with external Tide manufacturing partners to deliver the analytical aspects of GMP Tide API manufacture.
• The development of Tide APIs analytical control strategies, keeping a strong focus on quality for our patients.
• Identifying and solving potential analytical project issues.
• Planning and conducting lab-based experimental work in accordance with project timelines.
• Supporting the technical development of other scientists.
• Keeping abreast of scientific developments and proactively applying existing and novel approaches to projects.
• Authoring the Tide APIs CMC components of regulatory submissions and preparation of successful regulatory responses.
• Contributing to strategy for delivery of Tide products, including developing proposals for new internal and/or external S&T development programmes.
• Contributing to development of AZ Tide regulatory strategy.

Required Qualifications, Skills, Knowledge and Experience:

• A degree (BSc, MSc or equivalent) in Chemistry or Analytical Chemistry with a proven track record of analytical development in a pharmaceutical environment, or a PhD including aspects of analytical measurement.
• Knowledge and practical experience across a range of analytical techniques, e.g. LC, MS, GC, NMR and their application to Tide APIs analysis.
• Scientific leadership skills and the ability to use knowledge and experience to assess options available and deliver robust scientific contributions to projects
• Strong problem-solving skills, underpinned by strong practical laboratory experience
• Experience of working collaboratively within a mixed skill technical team and ability to develop and utilise networks
• Ability to communicate complex scientific information in a clear, concise and understandable way

Desirable Skills, Knowledge and Experience:

• Previous experience in analytical methods development and validation for the analysis of Tides API.
• Delivering Tide manufactures and Tide analytical development activities either via a CMO or within a CMO.
• Familiarity with methods and instruments used for Tides analysis such as LC (SEC, RP, IEX, HILIC), 2D-LC, FTIR, SEC-MALS and mass spec.
• Understanding of different types of impurities formed during Tide API manufacture and on storage. With awareness of required analytical controls.
• Ability to confidently and successfully lead improvement projects.
• Strong influencing, planning and prioritisation skills to ensure project delivery to deadlines.
• Experience of leading technical teams, coaching and people development.
• Commitment to improvement and innovation and knowledge of Lean principles.
• Knowledge and practical experience of quality and regulatory requirements (GMP and ICH) and health and safety requirements.
• Data science skills and data visualisation (PowerBI/Power Query)

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working give us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of five days per week from the office. But that doesn’t mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Why AstraZeneca?

At AstraZeneca, we're dedicated to being an outstanding Place to Work. Where you are empowered to push the boundaries of science and spark your high-reaching spirit. There’s no better place to make a difference to medicine, patients, and society. An inclusive culture that champions diversity and partnership, and always committed to lifelong learning, growth, and development. We’re on an exciting journey to pioneer the future of healthcare.

Are you ready to bring new insights and fresh thinking to the table, Brilliant! We have one seat available, and we hope it’s yours.

Competitive salary and benefits.

Date Posted

Closing Date

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.