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Director, Clinical Supply Early Synthetic - Oncology

AstraZeneca UK

Location: Cheshire East, Gaithersburg, Maryland

Job Type: Full time


Director, Clinical Supply Early Synthetic - Oncology

Gaithersburg (USA) Macclesfield (UK) Warsaw (Poland) Gothenburg (Sweden)

About the role

Director, Early Synthetic Oncology will lead a R&D therapy area sub team with a portfolio of internally or externally sponsored clinical trial programmes and will be fully accountable for the initial design and optimisation of drug supply within their specific sub therapy area ensuring no disruption to supply to patients which includes and not limited to new study start up. This role will be accountable for the initial design, development, and execution of the end-to-end supply chains within their span of control to meet patient needs and project timelines. This role will be critical in identifying potential opportunities for cost and lead-time reduction, incorporating sustainability opportunities ahead of transferring to the Late Synthetic Team.

This senior role is a global line leadership role within Clinical Manufacturing & Supply accountable for managing a team of Globally based (Snr) Clinical Supply Programme Leads to ensure effective balancing of demand and supply whilst delivering cost and turning point targets. This role is accountable for the financial forecasts for their portfolio of studies supporting SET governance and is accountable for ensuring the agreed landmarks and budgets are met.

The role is to play a pivotal leadership role in orchestrating the relationship and partnership with R&D Clinical Early Oncology, Global Medical Affairs, Pharm Sci, and internal PT&D Stakeholders, collaborating to drive innovation, improve outcomes and deliver business results.

This role will also be key in exploiting the understanding of product development, manufacture, and supply; assessing future clinical landscape and identifying supply chain strategies. There will be an expectation that this role leads supply chain initial feasibility studies to drive the understanding of the future expectations on CM&S

Key Accountabilities

Line Management of Globally based (Snr) Clinical Supply Programme Leads

  • Responsible for line management of the respective Clinical supply programme team members.

  • Responsible for the recruitment, training, and professional development of the team.

  • Translating strategy and objectives into a meaningful direction for the group that every individual connects with and fosters a great place to work climate.

  • Provide leadership, coaching, mentorship, and direction to team members and drive a strong lean culture that promotes standardization, simplification, and continual improvement.

  • Input into financial budgeting processes and delivery of group spend to budget.

Global Leadership and Orchestration of supply for Clinical Programmes

  • Ensuring effective and agile end to end supply chains meet agreed portfolio, project, clinical breakthroughs and ensures alignment of objectives through the line.

  • Accountable for the clinical supply input and supply chain design ahead of Senior Governance (ESPC) and ensures CM&S detail is provided to SVP via CM&S Leadership.

  • Accountable for delivery of clinical supply governance commitments.

  • Portfolio and capacity management for group fully aligned with budgeting processes.

  • Accountable for an efficient collaboration process with all relevant internal and external partners within the scope of clinical supply design and programme planning.

  • Accountable for driving end to end planning and synchronisation capability uplift.

Accountable for the Supply Chain Teams & Demand Forums

  • Ensures effective supply chain teams work in partnership with pharmaceutical project teams and have responsibility to set up and manage an effective and efficient supply chain to ensure timely delivery of investigational product to all clinical studies within a project.

  • Responsible for prioritization within the sub-therapy area to meet clinical requirements.

  • Delivery against functional KPI and metrics and monitoring of delivery towards clinical targets, customer concern and communication of risk, issues, and recovery plans

Orchestrates the synchronization for the clinical supply chain in and across the different supply chain nodes via the S&OP process

  • Accountable and or Chair for the Sr S&OP/IBP process (when developed) across Clinical and Finance

  • Accountable for clinical project spend for the sub-TA area (ca.$50m) and input into the financial processes (RBU; MTP; LTP; Phased Budget)

  • Accountable for actual clinical supply chain spend performance and tracking vs. budget.

Strategy Development

  • Collates the future business requirements for their sub-therapy area to develop clinical supply strategies that feed as a demand into the appropriate network strategies and the strategic workforce plan to develop clinical supply capabilities.

Business Process Management

  • Accountable for working with other Heads of Clinical Supply Chain Programmes and BPOs (Business Process Owner) to implement programme process standardization and engaging with the BPOs to ensure processes are more efficient or adapted to new business needs

Essential experience & Skills

  • Degree or equivalent experience or equivalent professional qualification

  • Extensive supply chain experience covering planning, logistics and manufacturing.

  • Strong influencer and effective senior stakeholder leadership skills.

  • Evidence of leading in a matrix environment with outstanding stakeholder management

At AstraZeneca, we are driven by our commitment to deliver accelerated growth and to make people's lives better. We thrive in our often intense and ambiguous environment, seeking out new challenges and working towards new solutions. We are part of an inclusive and giving community, where we support and help each other on our journeys. We are intellectually stimulated by constant learning and there's potential for multiple, global careers and great rewards, for those who embrace the diverse opportunities.

Are you ready to make a positive impact in a team where it means more? Join us at AstraZeneca, where we are truly changing the business. Apply now!

Closing date: Friday 1st December

Competitive salary & benefits offered

Date Posted


Closing Date


AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics (e.g. race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status). We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.