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Senior Scientist (B-Cell Technology), Discovery Platforms, Biologics Engineering, Oncology R&D

Full time
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AstraZeneca UK
Healthcare & medical
10,001+ employees
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Are you a seasoned scientist with expertise in; in vivo Antibody Drug Discovery using single B-cell technologies? Are you passionate about applying your skills to develop our single B-cell technology platforms and generate therapeutic antibody candidates? If so, this role at AstraZeneca is the perfect opportunity for you! Join us in our relentless pursuit of science, as we strive to turn ideas into life-changing medicines.


At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.


The role is based in our new groundbreaking Discovery Centre (DISC) located on the Cambridge Biomedical Campus. This newly purpose-built building that will bring together the company’s research and development activity in a pioneering strategic R&D centre and global corporate headquarters. The building has been designed with the open architecture reflecting AstraZeneca’s approach to research. Open laboratories and glass walls will enable new ways of working across teams, whilst a central courtyard will put science on full display.


At AstraZeneca, we are pioneers in Oncology. We push the boundaries of science to change the practice of medicine and transform the lives of patients living with cancer. With one of the broadest and deepest Oncology pipelines in the industry, we are committed to making a meaningful difference to people and patients around the world.

What you'll do

As a Senior Scientist, you will be a part of our B-Cell Technology Team within the Department of Biologics Engineering. Your role will involve applying and developing our single B-cell technology platforms to generate therapeutic antibody candidates. You will be instrumental in supporting the progression of diverse antibody discovery pipeline projects across various therapeutic areas.

Essential for the role

  • PhD in Immunology, Molecular Biology, Biochemistry or related discipline.

  • Antibody discovery expert with extensive experience & strong track record of delivery with in vivo based antibody discovery approaches (e.g. single B-cell technologies).

  • Solid knowledge of antibody sequence analysis (e.g. annotation, clustering).

  • Proficiency in designing and executing NGS library preparation protocols (including the use of 10x Genomics technology platform) for single-cell immune profiling (e.g. BCR), gene expression profiling, and ideally for spatial transcriptomics applications.

  • Proficiency in single-cell next-generation sequencing (NGS) data analysis methods for B-Cell Receptor Repertoire and Gene Expression profiling. Familiarity with software packages that enable immune and gene expression NGS data analysis at single cell level (e.g. Cell Ranger, MiXCR, Immcantation, Immunarch, Seurat and/or others), with the ability to extract meaningful insights from complex datasets.

  • Proven track record of innovation and problem-solving in antibody discovery, demonstrated by contributions to pipeline optimization and technology development initiatives.

  • Strong track record of general molecular biology skills & techniques (e.g. RT-PCR, Cloning (restriction enzyme and/or assembly methodologies), Sanger sequencing/analysis).

  • Strong, professional communication skills and excellent attention to detail, capable of developing good working relationships with diverse individuals.

  • Experience of complex data analysis, tracking & presentation to stakeholders.

  • Proactively develops knowledge.

Desirable for the role

  • Experience and track-record in working with flow cytometry and/or FACS, (ideally immune cells).

  • Experience with antibody screening and characterisation methods (e.g. ELISA, HTRF, SPR, BLI).

  • Hands on experience with microfluidic systems (e.g. droplet generation, screening).

  • Knowledge of Machine Learning and ideally its implementation in antibody drug discovery would be an advantage.

Why AstraZeneca?

Are you ready to be a part of this groundbreaking journey? Apply now and join us in our mission to eliminate cancer as a cause of death!

So, what’s next?

  • Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you!

Competitive salary package and benefits

Close Date: 11/04/2024

Where can I find out more?

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Date Posted


Closing Date

10-Apr-2024Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.