Scientist- Antibody Development

Company Description

For over 20 years, abcam has been providing tools the scientific community needs to enable faster breakthroughs in critical areas like cancer, neurological disorders, infectious diseases, and metabolic disorders.

We believe that to continue making progress, we need to work together in new ways. We need your own unique perspective as well as this of our people to make an always greater impact on the world. This community needs people like you: dedicated, agile and above all audacious so we can truly bring progress forward.

Job Description

The Antibody Development Scientist will be responsible for target level RAbMab development process control to drive target through technical scoping, immunization and development process to ensure high quality RabMabs to be developed for life sciences, across all delivery destinations (Custom, collaborator, partner or catalogue). The candidate will collaborate with RA leads, colleagues in protein science and production teams.

Roles & Responsibilities

• Responsible for the whole process of target level antibody development until publication. Ensure full alignment on the product level TPP at the start of the development process; verify delivery of the TPP with the responsible triad at the conclusion of the development process.
• Immunogen design based on database and target information. Study on target info based on published papers, commercially available antibody datasheet and Swiss-Prot. Identify the screening materials and commercially available benchmark to design experiments.
• Request immunization task, review the serum titer and make decision whether the project could be moved to next stage or it need further boost.
• Request fusion or sorting task, review the screening results, select the clone candidates for HT-Recombination and make decision whether it could be moved to next Recombination stage.
• Request recombination task and application test task; review results of application test and do troubleshooting if necessary and move the best clone candidates to sequencing process and Production stage.
• Request production task and do troubleshooting on issue projects with corresponding scientists from Manufacturing team. Request QC test task based on targets information and TPP.
• Data review of application results and do troubleshooting on issued projects at QC stage. Template preparation for Cam RabMab review meeting.
• Work closely with RA leads, colleagues in protein science, antibody screening and validation, production teams to ensure targets being processed to immunization and development process smoothly.
• Report progress to relevant stakeholders.

Qualifications

You will have a Ph.D. degree in life sciences with hands on experiences in sELISA, WB, FC, IHC, ChIP, IF/ICC, etc. and be able to do troubleshooting. Post Doc and industry experience are preferred. A solid record of accomplishments and publications as evidence of scientific knowledge. Outstanding communication, interpersonal and project management skills are all required to be successful in this role as well as being adaptable, motivated, and enthusiastic.
Experiences in immunogen design and epitope prediction are desirable however not essential.

Additional Information

We know that when it comes to benefits, no one size fits all. Flexibility and choice matter which is why in addition to market competitive salaries, we offer you a flexible benefits package which is tailored to your unique needs and support your financial, physical and emotional wellbeing. This includes our award-winning share scheme, 18 weeks fully paid maternity leave, 6 weeks fully paid paternity leave as well as highly flexible working and much more. Besides, your development will be integral to your experience here. You will grow alongside other talented minds, in ways you may often find unexpected.

When people come together, incredible things happen. Here you’ll work in a safe environment where you can be who you truly are. We’ll champion and celebrate your uniqueness throughout your journey with us. This is how we excel at partnering with the scientific community no matter the challenge, ultimately helping solve the world’s most critical diseases. Find out more about Diversity & Inclusion at abcam.

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