We are looking for someone who is a recognised expert in the field of Cell Line Engineering to join the Protein and Cell Sciences Team supporting our Biotherapeutics Discovery portfolio. In this role you will be responsible for a team of 5 scientists delivering Engineered Stable Cell Lines to support project milestones, from target identification and validation through to candidate drug nomination, as well as implementing process improvements and technology advancements.

ABOUT ASTRAZENECA

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies.

SITE DESCRIPTION

Welcome to Granta Park Cambridge, UK, one of over 400 sites here at AstraZeneca, providing a collaborative environment where everyone feels comfortable and able to be themselves is at the core of AstraZeneca’s priorities, it’s important to us that you bring your full self to work every day. To help you maintain your best self, here’s a sneak peek into some of the things this site provides for you… Granta Park has a newly built gym with swimming pool, nursery and central food hub accessible to staff as part of the science park facilities. We also have our own bistro and deli in the AstraZeneca buildings. There are regular ‘Lunch & Learn’ events and after work socials with snacks and drinks on the last Friday of every month. This is our biggest and most spacious lab site in Cambridge…come and join us!

BUSINESS AREA

In the Oncology Business Unit we relentlessly follow the science, challenging the status quo to deliver more effective treatments to patients in need. Our dedication means we purposefully push back the limits of knowledge to change the practice of medicine. To ensure no patient is left behind, no matter what stage of disease.

What you'll do

• Leads experimental strategies, and scientific resource in the technical area of Cell Line engineering to provide recombinant cell lines enabling biologics drug discovery and driving decision-making data for therapeutic biologics drugs projects

• Maintains and applies extensive expertise in developing engineered cell lines to facilitate biologics drug discovery – this includes target protein expression/overexpression, reporter cell lines and target protein knock out cell lines (CRISPR/Cas9) to facilitate the development of next generation biologics in immuno-oncology.

• Responsible for driving strategic alignment of our cell engineering capabilities

• Makes detailed observations, analyses data, interprets results and devises solutions to complex scientific problems

• Maintain a well-developed understanding of how cell line engineering enables antibody and next-generation biologics drug discovery (including alternative scaffolds, multi-specifics and ADC’s) and applies broader functional knowledge to support department initiatives

• Direct line management of a cell engineering team, setting goals aligned to department strategy, coaching, developing and managing staff performance

• Recognised as a specialist in their area of expertise. Establishes internal and external contacts and collaborations within scientific field of value to the business and presents at internal (intra- and inter-departmental) and external meetings

Essential requirements

• PhD with proven experience or BSc/higher degree with extensive lab-based experience

• A deep level of knowledge and strong technical skills in cell line engineering (e.g. molecular biology, lentivirus & plasmid based vector design, generation of stable pools and clonal cell lines; application of CRISPR/Cas 9; flow cytometry)

• Formal or informal line management experience, including coaching and staff development

• A history of successful project delivery and innovation, supported by publications and/or patents

• Excellent communication, capable of developing good working relationships with individuals across organisational boundaries and experience working within a team environment

• Background in drug discovery and development in the pharmaceutical industry

Desirable requirements

• Application of automation to cell line engineering and molecular biology

• Knowledge of target identification and validation strategies and experimental approaches

Competitive salary & benefits

Close date: 30/08/2023

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big.

So, what’s next!

• Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it’s yours.

Where can I find out more?

Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

Date Posted

Closing Date

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.