Associate Director, Translational PKPD

Waltham, Massachusetts
Full time
Posted
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AstraZeneca
Science & biotechnology
10,001+ employees
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Job Title: Associate Director, Translational PKPD

Introduction to role:
We are currently seeking an Associate Director in Translational PKPD. This is a unique opportunity to drive strategy and provide global leadership in DMPK science on Antibody Drug Conjugates (ADCs), Radio Immuno Conjugates (RICs), as well as small molecules. As an Associate Director, you will be providing projects with DMPK support, exploring the PK/PD/Efficacy relationships in pre-clinical models, and using these models to build a quantitative understanding of the dose & schedule requirements for therapeutic intervention across different patient populations as a single agent and combined with other agents.

Accountabilities:
In this role, you will be representing the Translational PKPD group and providing overall scientific leadership for cross functional and external collaborations involving DMPK. You will explore the effects on target and pathway to understand the requirements for efficacy and set a candidate drug target profile (CDTP). You will predict human dose and regimen together with providing input into exposure and pharmacodynamic (PD) biomarker based decision criteria for early clinical trials. You will drive learnings through back translation of early clinical exposure and PD data and provide prioritized future options for clinical testing. You will lead and participate in Oncology strategic scientific initiatives and continuous improvement projects by providing expert DMPK knowledge and participating in the development of Discovery or Development strategies in PKPD. You will work collaboratively and in continuity with other partner functions. You will have a breadth of influence and impact across AstraZeneca Clinical Pharmacology and externally within their discipline.

Essential Skills/Experience:
* PhD in a discipline with a significant component of analysis and quantitation, such as pharmaceutical sciences, quantitative pharmacology, pharmacometrics, engineering, physics, or applied mathematics, with a minimum of 2 publications in peer reviewed journals.
* Minimum 4 years of relevant industry experience in DMPK/preclinical/translational project-facing role within pharmaceutical R&D.
* Specialist in tools such as WinNonLin/Phoenix NLME, R, SimCYP , NonMem, Berkeley Madonna and MATLAB.
* Track record of supporting PK, PKPD and TKPD aspects of projects, with a delivery focus and ability to meet timelines to prespecified quality and cost.
* Strong publication record demonstrating comprehensive understanding of DMPK and pharmacology/safety aspects of drug discovery and development.

Desirable Skills/Experience:
* Excellent interpersonal and communication skills coupled with strong influence and leadership skills.

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Why AstraZeneca?
Join the team unlocking the power of what science can do. We are working towards treating, preventing, modifying and even curing some of the world's most complex diseases. Here we have the potential to grow our pipeline and positively impact the lives of billions of patients around the world. We are committed to making a difference. We have built our business around our passion for science. Now we are fusing data and technology with the latest scientific innovations to achieve the next wave of breakthroughs. It's our combination of curiosity and courage that drives us, inspired by the possibility of doing things that have never been done before. Empowered to step up, we free ourselves from fear of failure to dig deep into the biology of complex diseases and make bold decisions. Celebrating our successes and failures along the way.

Ready to embrace new and varied opportunities to develop and learn? Apply now!