Director, Solid Tumor TI/TV, Oncology R&D

Do you feel passionate about the possibilities of great science changing lives of cancer patients? Do you have a background within oncology research in target identification/validation and cancer biology, and have interest in finding new targets for AZ's growing portfolio of ADCs and Radioimmunoconjugates? If so, this may be the role for you.

We currently have an exciting opportunity for a highly motivated Director to lead a team of scientists across multiple AZ sites spearheading solid tumor target discovery, validation, and biology.

Within AstraZeneca Oncology R&D, we are committed to advancing the science to deliver life-changing medicines to patients most in need. With a combination-focused pipeline that exploits the power of six scientific platforms (Immuno-Oncology, Tumor Drivers and Resistance, DNA Damage Response, Antibody-drug Conjugates, Cell Therapy and Epigenetics) to help address unmet clinical needs in a host of cancers, we are motivated by a dedication to the scientific discovery and teamwork that will one day help eliminate cancer as a cause of death.

What you'll do

We are seeking a Director in Oncology Targeted Discovery (OTD) to develop a comprehensive strategy to discover and validate new targets for ADCs and RICs, as well as understand the role of targets in cancer biology. Working in partnership with the OTD team across the globe, lead the implementation of novel target biology and discovery efforts.

Responsibilities

• Lead a team across multiple sites focused on cancer biology-based target discovery and validation for ADCs and RICs

• Collaborate with internal teams to prioritize targets, develop target identification and validation strategies

• Support project teams with early validation work and exploration of target biology

• Interface with Tumor Councils and strategy teams to provide scientific leadership and gain feedback for ADC development

• Lead internal and external research collaborations supporting target discovery and biology

Essential for the role

• PhD and/or MD with experience in drug development

• A minimum of 6 years of relevant experience

• In-depth knowledge of tumor target identification strategies utilizing OMICS and functional screens

• Comprehensive knowledge of ADCs and oncology disease area biology (solid tumors); experience with ADCs is desirable

• Ability to drive, manage, execute and deliver results for complex multi-functional projects

• Highly developed problem solving and risk management skills, with attention to detail

• Highly developed collaborative working skills

• Ability to act as an external ambassador and to influence external organizations to enhance the image and reputation of AstraZeneca

• Established ability to lead a mid-size team including setting goals and objectives, empowering and developing team members

Desirable for the role

• Experience in target identification/validation for mAb therapeutics or ADCs in oncology.

When we put unexpected teams in the same room, we ignite bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

At AstraZeneca, we follow the science and pioneer new frontiers. We are a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development, and commercialization of prescription medicines for some of the world's most serious diseases. Our Oncology R&D team is deeply committed to transforming the lives of patients living with cancer, with the ultimate aim of eliminating cancer as a cause of death. We are uniquely placed with the funding, the ambition, and the bravery to make it happen.

Ready to join us in our mission? Apply now!