Senior Scientist Oncology Safety Combinations

AstraZeneca UK

Location: Cambridgeshire

Job Type: Full time


Senior Scientist Oncology Safety Combinations

Clinical Pharmacology & Safety Sciences

Cambridge UK

Salary & Benefits Competitive

Introduction to role:

Are you ready to make a more meaningful impact on patients’ lives around the globe? At AstraZeneca, we offer the opportunity to make a difference. With science at its heart, this is the place where breakthroughs born in the lab become transformative medicines for the world’s most complex diseases. We are seeking a highly motivated, skilled Senior Scientist with experience in cell biology. You will have the opportunity to work closely with a team of Scientists to apply ground-breaking technologies and push the boundaries of predictive safety science.


As a member of the Oncology Safety Combinations team within the Clinical Pharmacology and Safety Sciences department, you will work in close collaboration with other safety scientists to conduct pre-clinical safety assessments of new drug candidates, with a focus on bone marrow. You will actively contribute to the experimental design, practical delivery, and interpretation of data. Your expert knowledge will be crucial in addressing capability gaps by contributing to the further development of our experimental platforms, developing new endpoints, and incorporating mechanistic biomarkers.

Essential Skills/Experience:

- PhD or equivalent experience in cellular biology, pharmacology, immunology, toxicology or similar field”

- Ability to understand biology around novel targets and pathways to drive scientific testing

- Expertise in the design and execution of in vitro experiments to determine the effects of molecules on biological systems

- Proven experience in laboratory cellular biology techniques applied to development of physiologically relevant cellular assays to evaluate biological mechanisms

- Strong oral presentation and written communication skills

- Excellent team player

- Highly motivated, innovative scientist with a collaborative mentality and a desire to drive personal development

Desirable Skills/Experience:

- Experience in generating cellular growth inhibition curves using automated liquid handling platforms

- Understanding of the drug discovery process from experience in the biotech/pharmaceutical industry or via collaborations

- Practical experience and scientific knowledge of in vitro models of haematopoiesis

- Experience of 3D microphysiological systems

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn't mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

At AstraZeneca, we follow the science to explore and innovate. We are working towards treating, preventing, modifying and even curing some of the world's most complex diseases. Here we have the potential to grow our pipeline and positively impact the lives of billions of patients around the world. We are committed to making a difference. We have built our business around our passion for science. Now we are fusing data and technology with the latest scientific innovations to achieve the next wave of breakthroughs.

So, what’s next?

Complete your application before the below closing date.

This role is open from 30/01/2024 we welcome with your application no later than 27/02/2024.

Date Posted


Closing Date

27-Feb-2024Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.