Delivering on Analytical Chemistry strategies for the TTD chemistry-London group to impact project success towards platform development and up to candidate nomination of targeted therapeutics, including antibody drug conjugates (ADCs). Develop, validate and apply assays to understand the stability of small molecules and large molecules such as proteins, ADCs and related scaffolds in relevant biological matrices. You will work closely with scientists from other subject areas including Chemistry, Bioconjugation, Bioscience team, Bioanalysis, ADME/DMPK and Safety Sciences as part of the wider drug discovery project team and will present your work regularly to peers and senior partners.

About AstraZeneca

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies.

Site description

Our TTD-Chemistry site situated in Whitechapel, London is one of over 400 sites here at AstraZeneca, providing an environment where everyone feels comfortable and able to be themselves is at the core of AstraZeneca’s priorities, it’s important to us that you bring your full self to work every day. To help you maintain your best self, here’s a sneak peek into some of the things this site provides for you After-work events, Lunch & Learns, spacious balanced office working environment. Situated in the heart of London’s historical east end close to the fashionable areas of Shoreditch, Spitalfields and Brick Lane with excellent public transport links to central London.

Business area

In the Oncology Business Unit we relentlessly follow the science, challenging the norm to deliver more effective treatments to patients in need. Our dedication means we purposefully push back the limits of knowledge to change the practice of medicine. To ensure no patient is left behind, no matter what stage of disease. Fast-paced, it takes agility and responsiveness to stay committed in our pursuit of excellence. We work with focus to seek the unanswered questions – innovating, challenging accepted norms, quick decision-making and doing things differently. A place of trust, it’s an opportunity to take accountability, be brave, speak up, step up and redefine Oncology, now and in the future. Be a part of improving lives. This is the time to join the team who is confident that cures for cancer are within our grasp.

What you’ll do

• Devise and execute on analytical chemistry strategies, managing and mentoring a team of analytical scientists to deliver platform and pipeline focused drug discovery workflow for oncology and other therapeutic areas.

• Lead the review, approval and interpretation of data to ensure its high quality.

• Develop, optimize and validate assays to understand the stability of small molecules, ADCs and related conjugates under serum, proteases and lysosomal fractions.

• Deliver QC analysis of small molecules, intermediates, linker payloads, proteins, mAbs and related conjugates.

• Establish high throughput assays and implement automation to achieve project needs.

• Foster interdisciplinary teamwork and build strong relationships with partner lines to drive technological innovations and improve capabilities.

• Ensure own work, and the work of others, is performed in accordance with appropriate Safety, Health & Environment (SHE), quality and compliance standards.

• Perform other duties in line with the grade of the role.

Essential for the role

• Doctoral degree (Ph.D.) in Analytical chemistry, Biochemistry or other relevant fields.

• Relevant degree and or biotech/pharmaceutical industry experience, with a strong track record of scientific innovation and success in advancing candidates through milestones.

• Subject Matter Expert (SME) in mass spectrometry and related techniques. Hands on experience with Orbitrap, QToF or relevant MS instruments.

• Substantial experience with assay design, optimization and validation of stability assessments of small and large molecules in biological matrices.

• In-depth knowledge of the drug R&D process and demonstration of analytical related activities to achieve project milestones.

• Strong track record of effective line management and talent development.

• Track record of scientific innovation as evidenced by scientific publications, patents, and oral presentations at conferences.

• Strong oral and written communication skills, team-working and time-management skills.

• Experience with programming such as Python, R and automation of analytical workflow is advantageous.

• Experience with antibody drug conjugates is beneficial, but not required.

Why AstraZeneca?

At AstraZeneca, we 're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and ignite your entrepreneurial spirit.

So, what’s next?

• Are you already considering joining the team? Good, because we can’t wait to hear from you.

Competitive salary package and benefits

Close Date: 09/04/2024

Where can I find out more?

Our Social Media,

Our Social Media, Follow AstraZeneca on LinkedIn: https://www.linkedin.com/company/1603/

Inclusion & Diversity: https://careers.astrazeneca.com/inclusion-diversity

Career Site: https://careers.astrazeneca.com/

Date Posted

26-Mar-2024

Closing Date

08-Apr-2024Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.