Join our Immunology Bioscience team within the Early R&I department at AstraZeneca. We are seeking a highly motivated scientist with a strong understanding of adaptive and/or innate immunity. This lab-based position is based in Cambridge (UK) within AstraZeneca’s innovative laboratories in the Discovery Center (DISC). Here, you will follow the science to help drive innovation and advance medicine to help improve patient lives.

Accountabilities:

As a lab-based researcher, you will have significant opportunity to drive the direction of the work. Your research will focus on characterizing novel immunological pathways in health and disease to aid target validation and drug projects. You will implement drug discovery research experiments independently, communicate the results to team members, and interpret data. You will also contribute to the development of strategies for new target identification and validation.

Essential Skills/Experience:

- PhD degree in Immunology or relevant field
- Expertise in drug discovery projects in the immunology or a closely related field of biology is preferred
- Highly organized and self-motivated, with the ability to work independently as well as collaboratively within a team
- Expertise in primary human cell culture including co-culture models, ex-vivo functional assays, expertise in multi-panel FACS and/or mass cytometry (CyTOF), including both intracellular and extracellular cell surface markers are essential.
- Strong hands-on skills in basic biochemical and molecular techniques including cell culture, quantification of mRNA (qPCR) and protein expression; ELISA, Western blot, Immunoprecipitation and sample prep for mass spectrometry; generation of knock-out and knock-in cell lines using CRISPR/Cas9 gene editing technology

Desirable Skills/Experience:

- Knowledge of in vivo models of autoimmunity and inflammation are preferred.
- Knowledge of precision immunology strategies and related technologies is preferred.
- Strong written and oral communication skills and the ability to critically analyse data sets
- Proven ability to run collaborative efforts and use external resources to find the most effective solutions to drug discovery problems

At AstraZeneca, we follow the science to explore and innovate. We are working towards treating, preventing, modifying and even curing some of the world's most complex diseases. We have built our business around our passion for science. Now we are fusing data and technology with the latest scientific innovations to achieve the next wave of breakthroughs. We are committed to making a difference. It's our combination of curiosity and courage that drives us, inspired by the possibility of doing things that have never been done before.

Are you ready to join a team that's unlocking the power of what science can do? Apply now!

Date Posted

22-Mar-2024

Closing Date

07-Apr-2024Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.