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Associate Principal Bioinformatician, Biologics Engineering, Oncology R&D

AstraZeneca UK

Location: Cambridgeshire

Job Type: Full time


In this role, you will form part of a Bioinformatics team, working at the cutting edge of research and development to create novel bioinformatics pipelines for biologics engineering, customising NGS workflows, integrating ML approaches to inform lab experiments. You will also work closely with data management, software engineering, computational modelling, and machine learning with access to industry-leading biologics R&D data across AstraZeneca.


AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development, and commercialisation of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies.


The role is based in our new ground-breaking Discovery Centre (DISC) located on the Cambridge Biomedical Campus. This newly purpose-built building brings together the company’s research and development activity in a pioneering strategic R&D centre and global corporate headquarters. The building has been designed with open architecture reflecting AstraZeneca’s approach to research. Open laboratories and glass walls will enable new ways of working across teams, whilst a central courtyard will put science on full display. When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn't mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.


Join the Biologics Engineering team at AstraZeneca, where we are responsible for the discovery and optimisation of next-generation biological drug candidates across all key therapy areas. We are developing in-house biologics discovery platforms and novel drug modalities to address unmet medical needs. Be empowered to act fast on smart risks and keep ahead in the fast-paced Oncology field.

Essential for the role

  • Ph. D in bioinformatics or a related field; with relevant working experience

  • Experience in Illumina workflows, raw data analysis and NGS data integration and interpretation.

  • Ability to apply data analysis methods efficiently to large data sets

  • Experience with programming scientific applications

  • Ability to explore novel bioinformatic approaches to improve sensitivity and specificity of NGS based workflows.

Desirable for the role

  • Expertise in NGS workflows

  • Experienced with any of R, Python, shell scripting, Java or Rust programming languages

  • Experience with Kubernetes cluster and associated software e.g. kubeflow

  • Experience with create production quality code and software engineering techniques and practices. e.g. version control, Jira, Agile, Scrum, code reviews etc.

  • Familiarity with multiple R&D data types, especially as they relate to therapeutic area research.

  • Capability of managing multiple simultaneous projects

Why AstraZeneca?

An environment that fosters diversity and is always committed to lifelong learning, growth and development. We’re on a journey to pioneer the future of healthcare.

Close date: 24/04/2024

Competitive salary and benefits

So, what’s next?

  • Are you already considering joining the team? Good, because we can’t wait to hear from you.

Where can I find out more?

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Date Posted


Closing Date

22-Apr-2024Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.
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